Journal of Cancer Therapy, 2020, 11, 463-469 https://www.scirp.org/journal/jct ISSN Online: 2151-1942 ISSN Print: 2151-1934 DOI: 10.4236/jct.2020.118039 Aug. 18, 2020 463 Journal of Cancer Therapy Physical Exercise and Gene p53—A Mini Review Tayane Horstmann Cabral 1 , Ana Luiza Lozinski 1 , Gabriel Massao Tanaka 1 , Marco André Cardoso 1 , Rossana Baggio Simeoni 2,3 , Péricles Varella Gomes 4 , Zair Candido Oliveira Netto 1 , Luiz Cesar Guarita-Souza 2 , Julio Cesar Francisco 1* , Ricardo Correa Cunha 1 1 School of Health Sciences, Positivo University, Curitiba, Brazil 2 School of Medical Sciences, Pontifical Catholic University of Paraná, Curitiba, Brazil 3 The Paraná Institute of Technology, Curitiba, Brazil 4 GEL LAB, Michigan State University East Lansing, East Lansing, USA Abstract Cancer is a global problem that in addition to physical, emotional and physi- ological causes economic and social impacts. The p53 gene is a tumor sup- pressor gene found in many malignant and benign tumors; this has the pri- mary function of keeping cells at rest after damaging to DNA. The p53 acts in the maintenance of cellular homeostasis, mainly through autophagy, playing a role in cell cycle arrest, when necessary, thus avoiding mutated DNA repli- cation. When in the oncogenic environment in many cases it is mutated, los- ing much of its efficiency allowing tumor development. Studies show that ex- ercise can in the regular part of its pro-autophagic function even in the on- cology setting. Stimuli of moderate-intensity aerobic and predominance of submaximal seem to trigger the protective function of p53 in various cancer settings. Among the many changes that these pathology triggers were the ob- jective of this mini review is to relate the changes that exercise generates in p53 protein functions and their possible influence on tumor cells. Keywords p53, Physical Exercise, Gene Mutations, Autophagy 1. Introduction The tissues of the human body are formed by cells that multiply through a natu- ral and orderly process; when this multiplication enters an entropy state, the diseases that have in common the disordered growth of cells are triggered, that is, a malignancy; malignant neoplasms are called cancer and benign neoplasms How to cite this paper: Cabral, T.H., Lo- zinski, A.L., Tanaka, G.M., Cardoso, M.A., Simeoni, R.B., Gomes, P.V., Netto, Z.C.O., Guarita-Souza, L.C., Francisco, J.C. and Cunha, R.C. (2020) Physical Exercise and Gene p53—A Mini Review. Journal of Cancer Therapy, 11, 463-469. https://doi.org/10.4236/jct.2020.118039 Received: February 25, 2020 Accepted: August 15, 2020 Published: August 18, 2020 Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access