Journal of Behavioral and Brain Science, 2017, 7, 532-543 http://www.scirp.org/journal/jbbs ISSN Online: 2160-5874 ISSN Print: 2160-5866 DOI: 10.4236/jbbs.2017.711038 Nov. 21, 2017 532 Journal of Behavioral and Brain Science The Transcutaneous Vagus Nerve Stimulation Output of the NuCalm Device of Solace Lifesciences Is Found to Be a Multifractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress Sergio Conte 1 , Fang Wang 2 , Nicoletta Sala 3 , Francesco Losito Casciaro 1,4 , Franco Orsucci 5 , Giuseppe Serafini 6 , Ferda Kaleagasioglu 1,7 , Leonardo Mendolicchio 1,8 , Rich Norman 1 , Elio Conte 1 1 School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics, Bari, Italy 2 College of Science/Agricultural Mathematical Modeling and Data Processing Center, Hunan Agricultural University, Changsha, China 3 University of Lugano, ISSI/Cerfim, Lugano, Swizerland 4 Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy 5 Division of Psychology, University College, London, England 6 Tor Vergata University, Rome, Italy 7 Faculty of Medicine, Near East University, North Nicosia, Turkish Republic of Northern Cyprus 8 Clinic Villa Miralago, ASL Varese, Italy Abstract We have investigated the Nu Calm Transcutaneous Vagus Nerve Stimulation device of the NuCalm Solace Lifesciences founding that it gives a multifractal output. A diminishing fractal/multifractal HRV is consistently reported in li- terature as related to a serious Autonomic Nervous System (ANS) dysfunction that of course we observe in several psychological and psychiatric disorders. Therefore, we suggest the investigators to apply such a device in subjects af- fected from anxiety, depression and stress using the method of inducing tVNS stimulation. Keywords Depression, Anxiety, Stress, Transcutaneous Vagus Nerve Stimulation, How to cite this paper: Conte, S., Wang, F., Sala, N., Casciaro, F.L., Orsucci, F., Serafini, G., Kaleagasioglu, F., Mendolic- chio, L., Norman, R. and Conte, E. (2017) The Transcutaneous Vagus Nerve Stimula- tion Output of the NuCalm Device of So- lace Lifesciences Is Found to Be a Multi- fractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress. Journal of Behavioral and Brain Science, 7, 532-543. https://doi.org/10.4236/jbbs.2017.711038 Received: October 8, 2017 Accepted: November 17, 2017 Published: November 21, 2017