 1: 943963 (2010) ewsletter Dighe   943 HOSTGUEST CHEMISTRY: A OVERVIEW achiket S Dighe * 1 , Shashikant R Pattan 1 , Deepak S Musmade 1 , Mangesh B Hole 1 , Vinayak M Gaware 1 and Prerana A Chavan 1 1 Department Of Medicinal Chemistry,Pravara Rural College Of Pharmacy,Pravaranagar, M.S, India Summary Hostguest chemistry deals with the Complexation of organic compounds. It has wide applications in the field of synthetic chemistry, Drug discovery and dosage form designing. It also plays a role in catalysis, scavenging and development of sensors. It has importance in drug delivery systems. Macrocycles has been used in anti cancer, antiviral, antifungal therapy along with active constituents to alter solubility, stability and to minimize the side effects. It also plays a role in mimicking drug action especially drug receptor interaction. The nature and chemistry of receptors can easily be understood with the help of Hostguest chemistry. Thus it has been proved to be effective tool for current research in pharmaceuticals. Key words: Catalysis, crown ethers, Hostguest chemistry, Macrocycles, Scavengers, Supramolecular complexes. *Address for correspondence Mr. achiket S Dighe Assistant Professor & HOD Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P Loni Bk.Taluka Rahata,DistAhmednagar 413736, India (MS). Phone no:+919890215729. E mailnachiket1111@rediffmail.com