Stability evaluation of [
18
F]FDG: literature
study, stability studies from two diferent PET
centres and future recommendations
Jes G. Holler
1
, Børge Renmælmo
2
and Richard Fjellaksel
3*
Background
Tere is a need for an [
18
F]FDG stability evaluation guide/checklist for radiopharmaceu-
tical production sites. [
18
F]FDG has been adopted worldwide as the most widely used
clinical positron emission tomography (PET) radiotracer since the frst in human PET
imaging in 1976 (Hess et al. 1976). Tere are several stability studies available. Hung
(2002) compares diferent quality tests and demands in the United States Pharmaco-
peia) USP/European Pharmacopeia (Ph. Eur.)/Te draft Chemistry, Manufacturing, and
Controls (CMC) issued by the U.S. Food and Drug Administration (FDA) and Yu (2006)
uses BP (British Pharmacopeia) as a quality reference standard (Hung 2002; Yu 2006).
However, there is no review on updated stability evaluation based on available literature,
recommendations and implementation for good manufacturing practice (GMP). Herein,
we present a non-systematic literature study, stability studies of [
18
F]FDG from two
Abstract
Background: The need for a stability evaluation of [
18
F]FDG is evident. The main pur-
pose of this study was to make recommendations for determining the shelf life based
on the available stability literature and our own two-centre stability studies.
Results: We performed a non-systematic literature study to fnd the most relevant sta-
bility data for [
18
F]FDG. The amount of radioactivity, radio-stabilizers, choice of synthe-
sis, dilution, pH, temperature, storage and the choice of stability tests and acceptance
criteria were the most important factors to evaluate for the implementation of good
manufacturing practice. Moreover, we discuss some limitations of the study, especially
the choice of synthesis, photostability, the environment, temperature and storage.
Based on these data, we designed our own two-centre stability studies. All the defned
acceptance criteria were met.
Conclusions: We have made recommendations for future stability evaluations based
on our fndings. The most important fndings were that the amount of the radio-
stabilizer ethanol should be > 0.1 % ethanol for activities up to 4 GBq/mL and > 0.2 %
ethanol for activities up to 22.7 GBq/mL to keep [
18
F]FDG stable.
Keywords: [
18
F]FDG, Stability, Quality control, Physiochemical aspects, Drug product
development, Radiopharmaceutics, Pharmaceutics, Manufacturing process design
Open Access
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RESEARCH ARTICLE
Holler et al.
EJNMMI Radiopharmacy and Chemistry (2022) 7:2
https://doi.org/10.1186/s41181-022-00154-3
EJNMMI Radiopharmacy
and Chemistry
*Correspondence:
Richard.fellaksel@uit.no
3
Department of Health
and Care Sciences, UiT The
Arctic University of Norway,
Hansine Hansens veg 18,
9019 Tromsø, Norway
Full list of author information
is available at the end of the
article