  Citation: Adly, W.M.R.M.; Mazrou, Y.S.A.; EL-Denary, M.E.; Mohamed, M.A.; Abd El-Salam, E.-S.T.; Fouad, A.S. Boosting Polyamines to Enhance Shoot Regeneration in Potato (Solanum tuberosum L.) Using AgNO 3 . Horticulturae 2022, 8, 113. https://doi.org/10.3390/ horticulturae8020113 Academic Editor: Kin-Ying To Received: 13 December 2021 Accepted: 17 January 2022 Published: 27 January 2022 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil- iations. Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). horticulturae Article Boosting Polyamines to Enhance Shoot Regeneration in Potato (Solanum tuberosum L.) Using AgNO 3 Walaa M. R. M. Adly 1 , Yasser S. A. Mazrou 2,3 , Mohammad E. EL-Denary 1, *, Mahasen A. Mohamed 1 , El-Sayed T. Abd El-Salam 4 and Ahmed S. Fouad 4 1 Horticulture Research Institute, Agriculture Research Center, Giza 12619, Egypt; DR.Walaa.Adly@gmail.com (W.M.R.M.A.); dr.mahasen.hakem@gmail.com (M.A.M.) 2 Business Administration Department, Community College, King Khalid University, Guraiger, Abha 62529, Saudi Arabia 3 Department of Agriculture Economic, Faculty of Agriculture, Tanta University, Tanta 31527, Egypt; yasser.mazroua@agr.tanta.edu.eg 4 Botany and Microbiology Department, Faculty of Science, Cairo University, Giza 12613, Egypt; tsayed1969@hotmail.com (E.-S.T.A.E.-S.); ahmedsfouad@yahoo.com (A.S.F.) * Correspondence: dr.m.eldenary@gmail.com Abstract: Advancements in shoot regeneration systems support biotechnology-based tools used in the genetic improvement of plant crops. This study aims to enhance shoot regeneration in potatoes by boosting polyamine content by adding AgNO 3 to the shoot regeneration medium (MS medium supplemented with 30 g L 1 sucrose, 100 mg L 1 myoinositol, and 2.25 BA mg L 1 ). Five concentrations of AgNO 3 (2, 4, 6, 8, and 10 mg L 1 ) were used in addition to a control. The effect of AgNO 3 on regeneration assumed a more or less concentration-dependent bell-shaped curve peaking at 4 mg L 1 . Enhancements in shoot regeneration were attributed to the known role of AgNO 3 as an ethylene action blocker in addition to improvements in polyamine accumulation without an increase in H 2 O 2 content, lipid peroxidation, or DNA damage. The uncoupling of shoot regeneration and polyamine content recorded at high AgNO 3 concentrations can be attributed to the consumption of polyamines to counteract the synchronized oxidative stress manifested by increases in H 2 O 2 content, lipid peroxidation, and DNA damage. Keywords: potato; polyamines; callus; shoot regeneration; H 2 O 2 ; MDA; comet 1. Introduction Potato (Solanum tuberosum) is the most important non-cereal food crop with annual world production of 370 million tons harvested from 17.34 million hectares (FAO 2019 https://www.fao.org/faostat/ar/#data/QCL, accessed on 11 November 2021). Tubers are an essential origin for energy and protein. They also introduce essential nutrients to a diet, including vitamins (B 1 ,B 3 ,B 6 and C), minerals (potassium, phosphorus, magnesium, zinc, and iron) in addition to folate, pantothenic acid, riboflavin, and dietary fiber [1]. Compared to other food crops, potatoes can produce more energy, proteins, minerals, and vitamins per unit of time and land area [2]. In addition to indoor uses, potatoes are used in many food industries [3] that generate a huge amount of peel used in bioethanol production [4]. Conventional potato breeding is a difficult task due to the tetraploid nature and high heterozygosity of the potato genomes. The first is responsible for inbreeding depression and intra-species incompatibilities, while the second prevents the incorporation of new traits through conventional breeding [5]. In addition, searching for functional genetic variability in wild relatives is laborious and time-consuming [6,7]. Biotechnology can hasten potato breeding through in vitro selection [8] and transfor- mation [9]. However, biotechnological tools require establishing a regeneration system to obtain genetically improved lines [10]. Thus, studying factors affecting regeneration in Horticulturae 2022, 8, 113. https://doi.org/10.3390/horticulturae8020113 https://www.mdpi.com/journal/horticulturae