* Corresponding author. E-mail address: ravibansal880@gmail.com (R. Bansal) © 2017 Growing Science Ltd. All rights reserved. doi: 10.5267/j.ccl.2017.3.001 Current Chemistry Letters 6 (2017) 135–142 Contents lists available at GrowingScience Current Chemistry Letters homepage: www.GrowingScience.com One-pot multi-component green synthesis of highly substituted piperidines Ravi Bansal * , Pradeep K. Soni, Jyoti Sharma, Santosh K. Bhardwaj and Anand K. Halve School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.) INDIA- 474011 C H R O N I C L E A B S T R A C T Article history: Received January 2, 2017 Received in revised form March 1, 2017 Accepted March 6, 2017 Available online March 6, 2017 An effective and expeditious method of the synthesis of a highly functionalized piperidines, catalyzed by nontoxic, recyclable and environment friendly sodium lauryl sulfate (SLS), via one-pot multi-component condensation of aldehydes, amines and β-ketoesters in water at room temperature, has been developed. This new protocol has advantages such as moderate to high yields of products obtained after simple post reaction workup. Structure of the synthesized compounds 4a–4j have been elucidated based on the 1 H NMR, 13 C NMR, FT-IR spectroscopy and elemental analysis. © 2017 Growing Science Ltd. All rights reserved. Keywords: Heterocycles Piperidines Multi-component synthesis Catalyst Sodiumlaurylsulfate (SLS) 1. Introduction Heterocyclic compounds containing nitrogen atom are wide spread in nature and have significant practical importance because of their applications in medicine and agriculture. 1,2 They are also used as functional materials. The development of new and efficient methods for the synthesis of N-heterocycles is one of the greater interests of modern synthetic organic chemistry. 3-5 Synthesis of complex heterocyclic molecules can be easily achieved starting from readily available starting materials in a single step multi-component reactions (MCRs). 6 In most of the cases these reactions are advantageous over the linear step-wise syntheses because of the operational simplicity, shorter reaction time, ecological concerns, low processing costs and avoidance of protection and deprotection processes. 7 Substituted piperidines are widely present in naturally occurring and synthetic drugs. 8 A variety of structural features are exhibited by synthetically prepared piperidines including many significant biological activities. Many methods have been extensively studied for the synthesis of piperidines because of their antihistamic, 9 anti-HIV, 10 anticancer, 11 antimicrobial, 12 anti-malarial, 13 anti- inflammatory, 14 insecticidal 15 and other biological activities.