Govaresh/ Vol.18/ No.3/ Autumn 2013 INTRODUCTION 6LO\PDULQ LV D XQLTXH ﾀDYRQRLG FRPSOH[ GHULYHG from the milk thistle plant. This plant is the subject of GHFDGHV RI UHVHDUFK LQWR LWV EHQHｿFLDO SURSHUWLHV WKDW include liver protection and decongestant effects(1-3). .QRZQ EHQHｿFLDO HIIHFWV LQFOXGH UHJHQHUDWLQJ OLYHU cells damaged by alcohol or drugs, decongestion of the liver, protection against industrial poisons such as carbon tetracholoride, protection of the liver against pharmaceuticals that stress the liver caused by some antibiotics and analgesics, treatment of viral hepatitis Effects of Silymarin on Reducing Liver Aminotransferases in Patients with Nonalcoholic Fatty Liver Diseases Mohesn Masoodi 1,2,3,4 , Amirmansoor Rezadoost 1,2 , Mohammad Panahian 1,2 , Mahdi Vojdanian 4 1 Colorectal Research Center, RasoolAkram Hospital, Iran University of Medical Sciences, Tehran, Iran 2 Gastrointestinal and Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran 3 Digestive Disease Research Institute (DDRI), Tehran University of Medical Sciences, Tehran, Iran 4 Tropical and Infectious Disease Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Original Article *RYDUHVK 9RO  1R $XWXPQ   Corresponding author: Mohsen Masoodi, MD Department of Internal Medicine, RasolAkram Hospital, Tehran University of Medical Sciences, Tehran, Iran Tel: + 98 21 64352485 Fax:+ 98 21 66554064 E-mail: Masoodi47@yahoo.com Received: 25 Apr. 2013 Edited: 30 Jul. 2013 Accepted: 31 Jul. 2013 Background: 7KH KHSDWRSURWHFWLYH HIIHFWV RI VLO\PDULQ KDYH EHHQ FRQｿUPHG E\ YDULRXV UHVHDUFKHUV ZRUOGZLGH KRZHYHU IHZ studies are available about the therapeutic impact of silymarin on the level of aminotransferases in patients with nonalcoholic steatohepatitis (NASH). Our purpose is to determine whether silymarin improves the serum level of aminotransferases in patients with NASH. Materials and Methods: This was a double blind, randomized, placebo-controlled trial performed on 100 patients with NASH. Subjects were UDQGRPL]HG WR UHFHLYH VLO\PDULQ  PJTK IRU WKUHH PRQWKV RU SODFHER JLYHQ LQ WKH VDPH PDQQHU $ EORRG sample was drawn at baseline (before treatment) and after completion of the treatment schedule to assess serum aminotransferase levels. We measured body mass index (BMI) before and after administration of the treatments for both groups of patients. Results: 7KHUH ZHUH LQVLJQLｿFDQW FKDQJHV LQ %0, IRU ERWK JURXSV 7KH PHDQ VHUXP DODQLQH DPLQRWUDQVIHUDVH $/7 OHYHO LQ WKH FDVH JURXS VLJQLｿFDQWO\ FKDQJHG IURP  WR  ,8P/ IROORZLQJ WUHDWPHQW ZLWK VLO\PDULQ p<0.001), KRZHYHU WKLV FKDQJH ZDV QRW VLJQLｿFDQW LQ WKH FRQWURO JURXS 7KH PHDQ VHUXP DVSDUWDWH DPLQRWUDQVIHUDVH $67 OHYHO LQ WKH FDVH JURXS VLJQLｿFDQWO\ GHFUHDVHG IURP  WR  ,8P/ DIWHU WUHDWPHQW ZLWK VLO\PDULQ 7KLV FKDQJH LQ WKH SODFHER JURXS ZDV QRW VLJQLｿFDQW IURP  WR  ,8P/ Conclusion: Administration of silymarin can effectively reduce liver aminotransferases without any changes in BMI in patients with NASH disease. Keywords: Silymarin; NASH; ALT; AST please cite this paper as: Masoodi M , Rezadoost A, Panahian M, Vojdanian M. Effects of Silymarin on Reducing Liver Aminotransferases in Patients with Nonalcoholic Fatty Liver Diseases. Govaresh 2013;18:181-5. ABSTRACT 181