ORIGINALARTICLE and hemodynamic instability. Therefore, it might increase the postoperative complications especially in high-risk patients. Moreover, shivering is one of the leading causes of discomfort for postsurgical 1 patients. In previous studies, various techniques have been used to alleviate the postoperative 2 shivering. We compared the effect of single dose of intravenous ondansetron versus tramadol on shivering and nausea/vomiting in patients undergoing cesarean section under spinal anesthesia. Intra- and postoperative shivering remain the common problem after surgery under spinal anesthesia. Shivering may increase cardiac output, circulating catecholamines, intracranial and Introduction Shivering is one of the common complications of anesthesia. It leads to increase oxygen consumption and increases the risk of hypoxemia and lactic acidosis which increases the catecholamine release Comparison of Intravenous Ondansetron versus Intravenous Tramadol on Post-Spinal Shivering and Nausea/Vomiting in Cesarean Sections 1 1 2 1 2 2 2 Sanum Kashif , Faisal Azam , Khalid Mehmood , Saira Tasneem , Asad Shamim , Fawad Alam , Tasneem Alam Correspondence: Maj Dr. Sanum Kashif Department of Anesthesia Frontier Corps Hospital, Quetta E-mail: sanumdr@gmail.com 1 Department of Anesthesia Frontier Corps Hospital, Quetta 2 Department of Anesthesia Combined Military Hospital, Quetta Life & Science 2020 Vol. 1, No. 4 Comparison of Intravenous Ondansetron versus Intravenous Tramadol Funding Source: NIL; Conflict of Interest: NIL Received: Feb 15, 2020; Revised: Jun 04, 2020 Accepted: Sep 18, 2020 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Objective: To compare the effect of intravenous ondansetron versus intravenous tramadol on post-spinal shivering and nausea/vomiting in caesarean sections. Study Design: Prospective comparative study Place and Duration of study: The study was carried out at Department of Anesthesia, Frontier Corps Hospital nd st Quetta from 2 July 2019 to 1 November 2019. Materials and Methods: Ninety patients, who were scheduled for elective cesarean section under spinal anesthesia were randomly allocated to one of three study groups to receive intravenous ondansetron (group O), tramadol (group T) or normal saline/placebo (group P). Intra- and post-operative shivering score, nausea/vomiting score and hemodynamic changes were recorded. Descriptive data was expressed as means and standard deviations (SD). Analysis of variance (ANOVA) and repeated measure analysis were used for continuous parametric variables. Within groups, comparisons were made using the Tukey's post-hoc analysis. Chi-square test was used for association of shivering and nausea/vomiting among the groups. Results: Both groups were comparable for the age and weight. Shivering was reported 0.35±0.59 in ondansetron group 0.73±0.55 in Tramadol group and 1.90±0.84 in Placebo group (p value< 0.001). Postoperative nausea and vomiting (PONV) was reported 0.25±0.53 in ondansetron group 1.04±0.63 in tramadol group and 0.99±0.71 in placebo group (p value<0.001).There was a significant difference in post- spinal shivering and nausea/vomiting in ondansetron (O) group versus tramadol (T) group and placebo group. Conclusion: The effect of intravenous ondansetron is better than intravenous tramadol in preventing shivering as well as nausea/vomiting. Key Words: Cesarean Section, Shivering, Nausea/Vomiting, Ondansetron, Spinal Anesthesia, Tramadol. How to cite this: Kashif S, Azam F, Mehmood K, Tasneem S, Shamim A, Alam F, Alam T. Comparison of Intravenous Ondansetron versus Intravenous Tramadol on Post-Spinal Shivering and Nausea/Vomiting In Cesarean Sections. Life and Science. 2020; 1(4): 156-161. doi: http://doi.org/10.37185/LnS.1.1.102 156