Int..J. De\". BinI. 38: 13-25 (1994) 13 Review Regulation of microtubule dynamics by microtubule- associated protein expression and phosphorylation during neuronal development JESUS AVllA*, JORGE DOMiNGUEZ and JAVIER DiAZ-NIDO' Centro de Biologfa Molecular ((Severo Ochoa!!, Universidad Aut6noma, Madrid, Spain CONTENTS Inlroduclion 14 Role of microtubule-associated proteins in the regulation of microtubule dynamics 14 MAP 1 proteins 1 5 MAP1 phosphorylation 16 Other brain MAPs 16 MAP2 16 MAP2 phosphorylation 17 MAP3/MAP4 18 Tau 18 Tau phosphorylation 19 Conclusions and perspectives 19 Summary and key words 20 References 21 .Address for reprints; Centro de Biologia Molecular "Severo Ochoau, Universidad Aut6noma, Canto blanco, E-28049 Madrid, Spain. FAX: 34-1-3974799. 1Present address: Beckman Neuroscience Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. 0214-6282/94/S03.00 '" use Pr~" Printed in Spain