897
van Onna, et al: GP recognition of axSpA
Personal non-commercial use only. The Journal of Rheumatology Copyright © 2014. All rights reserved.
General Practitioners’ Perceptions of Their Ability to
Identify and Refer Patients with Suspected Axial
Spondyloarthritis: A Qualitative Study
Marloes van Onna, Simone Gorter, Aniek van Meerendonk, and Astrid van Tubergen
ABSTRACT. Objective. To explore the knowledge, beliefs, and experiences of general practitioners (GP) about
inflammatory back pain (IBP) and axial spondyloarthritis (axSpA) and potential barriers for referral
of patients suspected of having axSpA.
Methods. A qualitative study involving semistructured interviews with GP was conducted.
Transcripts of the interviews were independently read and annotated by 2 readers. Illustrative themes
were identified and a coding system to categorize the data was developed.
Results. Ten GP (all men; mean age 49 yrs) were interviewed. All could adequately describe
“classic” ankylosing spondylitis (AS) and mentioned chronic back pain and/or stiffness as key
features. All GP thought that AS is almost exclusively diagnosed in men. Six GP knew that there is
a difference between mechanical back pain and IBP, but could recall only a limited number of
variables indicative of IBP, such as awakening night pain (4 GP), insidious onset of back pain (1
GP), improvement with movement (1 GP), and (morning) stiffness (2 GP). Two GP mentioned
peripheral arthritis as other SpA features, none mentioned dactylitis or enthesitis. GP awareness of
associated extraarticular manifestations was low. Most GP expressed that (practical) referral
measures would be useful.
Conclusion. GP are aware of “classic”, but longterm features of axSpA. Knowledge about the
disease spectrum and early detection is, however, limited. Addressing these issues in training
programs may improve recognition of axSpA in primary care. This may ultimately contribute to
earlier referral, diagnosis, and initiation of effective treatment in patients with axSpA. (First Release
April 1 2014; J Rheumatol 2014;41:897–901; doi:10.3899/jrheum.131293)
Key Indexing Terms:
INFLAMMATORY BACK PAIN AXIAL SPONDYLOARTHRITIS PRIMARY CARE
From the Department of Medicine, Division of Rheumatology, Maastricht
University Medical Center; The School for Public Health and Primary
Care (CAPHRI), University of Maastricht, Maastricht, The Netherlands.
A goodwill donation for the interviews with the general practitioners was
provided by Abbvie.
M. van Onna, MD; S. Gorter, MD, PhD, Department of Medicine,
Division of Rheumatology, Maastricht University Medical Center and
CAPHRI, University of Maastricht; A. van Meerendonk, MD, Department
of Medicine, Division of Rheumatology, Maastricht University Medical
Center; A. van Tubergen, Department of Medicine, Division of
Rheumatology, Maastricht University Medical Center and CAPHRI,
University of Maastricht.
Address correspondence to Dr. M. van Onna, Department of Medicine,
Division of Rheumatology, Maastricht University Medical Center and
School for Public Health and Primary Care (CAPHRI), University of
Maastricht, P. Debyelaan 25, 6202 AZ, Maastricht, The Netherlands.
E-mail: m.van.onna@mumc.nl
Accepted for publication January 21, 2014.
Spondyloarthritis (SpA) comprises a group of interrelated
inflammatory disorders with overlapping clinical features
and shared genetic markers. The estimated prevalence of
SpA in white populations is about 1%, similar to that of
rheumatoid arthritis
1
. Symptom patterns and physical signs
of SpA can be divided into predominantly axial involve-
ment, with inflammatory back pain (IBP) as the most
important clinical feature and predominantly peripheral
involvement including peripheral arthritis, dactylitis, and
enthesitis
2
. Extraarticular manifestations related to axial and
peripheral SpA include psoriasis, anterior uveitis, and
inflammatory bowel disease.
Axial SpA (axSpA) comprises a disease continuum,
including both nonradiographic axSpA and ankylosing
spondylitis (AS)
3
. Patients with nonradiographic axSpA
have similar clinical characteristics, disease activity, and
response to treatment as patients with established AS,
emphasizing the need for early and correct diagnosis
4
.
However, the diagnosis of axSpA is often delayed owing to
the insidious onset, the heterogeneous clinical picture, and a
limited knowledge about the manifestations belonging to
axSpA by general practitioners (GP) or other referring physi-
cians
5
. Offering tools for referral may be helpful in
improving early diagnosis. Several initiatives have been
performed to study the effect of referral strategies in primary
care. The objectives of these referral programs were to
identify patients with possible axSpA early, to make a correct
diagnosis, and to provide the best possible care as early as
possible
6
. However, limited knowledge of manifestations
belonging to axSpA might prevent successful implemen-
tation of these referral strategies in the primary care setting.
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