1 Dopamine modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses Jessica Mitlöhner 1 , Rahul Kaushik 2 , Hartmut Niekisch 3 , Armand Blondiaux 1 , Christine E. Gee 4 , Max F.K. Happel 3 , Eckart Gundelfinger 1,6,7 , Alexander Dityatev 2,6,7# , Renato Frischknecht 1,5,6# , Constanze Seidenbecher 1,6,7,# 1 Leibniz Institute for Neurobiology (LIN), Department of Neurochemistry and Molecular Biology, 39118 Magdeburg, Germany 2 German Center for Neurodegenerative Diseases (DZNE), Molecular Neuroplasticity Group, 39120 Magdeburg, Germany 3 Leibniz Institute for Neurobiology (LIN), Department of Systems Physiology of Learning, 39118 Magdeburg, Germany 4 Center for Molecular Neurobiology Hamburg (ZMNH), Institute for Synaptic Physiology, 20251 Hamburg, Germany 5 current address: FAU Erlangen-Nürnberg, Animal Physiology, Department of Biology, 91058 Erlangen, Germany 6 Center for Behavioral Brain Sciences (CBBS), 39120 Magdeburg, Germany 7 Otto-von-Guericke University, Medical Faculty, 39120 Magdeburg, Germany # corresponding authors: Prof. Dr. Constanze Seidenbecher seidenc@lin-magdeburg.de Dr. Renato Frischknecht renato.frischknecht@fau.de Prof. Alexander Dityatev alexander.dityatev@dzne.de Keywords: ADAMTS 4/5, brevican, chondroitin sulfate proteoglycan, D1/D5 receptors, NMDA receptors . CC-BY-ND 4.0 International license not certified by peer review) is the author/funder. It is made available under a The copyright holder for this preprint (which was this version posted August 1, 2019. . https://doi.org/10.1101/722454 doi: bioRxiv preprint