Volume 2 | Issue 1 | 1 of 4 Int J Diabetes Metab Disord, 2017 Association between Serum Lipid Profle and Glycated Hemoglobin in Middle Aged Pre-Diabetic Individuals: Te Bangladesh Study Research Article 1 Department of Biochemistry, Mugda Medical College, Dhaka 2 Department of Biochemistry, BIRDEM General Hospital 3 Department of surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka 4 Laboratory Services Division, BIRDEM General Hospital 5 Vice principal, Mugda Medical College, Dhaka * Corresponding author: Afsana Begum, Department of Biochemistry, Mugda Medical College, Mugda, Dhaka, Bangladesh, E-mail: afsana42@yahoo. com. Submitted: 15 Nov 2016; Accepted: 28 Mar 2017; Published: 06 Apr 2017 A Begum 1 *, Muttalib MA 2 , N Arefn 3 , S Choudhury 4 and Shah Golam Nabi 5 International Journal of Diabetes & Metabolic Disorders Abstract Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is often preceded by a prodromal condition termed pre-diabetes. Pre-diabetes is a condition in which the blood glucose level is above normal but below the diagnostic threshold for diabetes mellitus. Impaired lipid profle is commonly present in type 2 diabetes and can also occur in pre-diabetes. The present study was undertaken to evaluate the association between serum lipid profle and glycated hemoglobin in pre-diabetic individuals in middle-aged Bangladeshi subjects. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) hospital, from July 2013 - June 2014. A total 131 subjects of age within the range of 30-45 years were selected for the purpose and classifed into apparently healthy control (n=62), pre-diabetes (n= 69) groups based on the values of OGTT. Blood glucose – both fasting and 2hr after glucose, HbA1C, total cholesterol, triglyceride, high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol level were measured in all study subjects. Among the middle aged Bangladeshi subjects attending BIRDEM hospital, mean±SD of HbA1c values were 5.3±1.1% in control group and 5.9±1.2% in pre-diabetes. There was no signifcant difference in total cholesterol, triglyceride, HDL-c and LDL-c in patients with normal and Pre-diabetic individuals. According to this study, HbA1c value does not correlate well with total cholesterol, triglyceride and LDL-c (p=0.47, 0.93, 0.49) in patients with pre-diabetic individuals. Studies on larger population are required to determine the prognostic implication of routine lipid profle. ISSN 2475-5451 Keywords: Pre-diabetes, HbA1C, Total cholesterol (TC), Triglyceride (TG), High density lipoprotein (HDL-C) cholesterol, Low density lipoprotein (LDL-C) cholesterol. Introduction Diabetes mellitus has become a global pandemic, generating overwhelming costs and burdens upon patients as well as health care providers. In Bangladeshi population, 8.4 million people have diabetes with a prevalence rate of 9.6%, which is expected to reach 11 million by 2030 (International Diabetes Federation). The pathological complications of this disease are associated with increased mortality and morbidity [1-4]. Pre-diabetes is a condition in which the blood glucose level is above normal but below the diagnostic threshold for diabetes mellitus [5]. According to National diabetes fact sheet 2011, in United States 79 million people were in pre-diabetic phase. The American Diabetes Association reports that approximately 11% of people with pre- diabetes who receive no treatment or intervention will develop type 2 diabetes every year [6]. Impaired glucose metabolism includes two conditions: Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT). IFG is a condition when fasting blood glucose levels are higher than normal but below the cut off used for diagnosing diabetes mellitus i.e. 110-125 mg/dl (6.1-6.9 mmol/l) while IGT, a condition when 2 hr postprandial blood sugar level are higher but still below the cut off used for diagnosing diabetes between i.e. 140-199 mg/dl (7.8- 11.0 mmol/l). Pre-diabetes are characterized by either impaired fasting glucose and impaired glucose tolerance or glycated hemoglobin (HbA1c) level between 5.7%-6.4% or both [7]. Pre-diabetes is multi factorial and common risk factors includes being overweight especially those who have excess weight around the waistline, physical inactivity, dyslipidemia (high triglycerides and low high density lipoprotein cholesterol and/ or high total cholesterol), high blood pressure, polycystic ovarian syndrome, gestational diabetes, family history of type 2 diabetes and/or heart disease. Pre-diabetes occurs 73.4% more frequently in people with family history of diabetes as compared to those without family history [8].