American Journal of Pediatrics 2020; 6(1): 52-57 http://www.sciencepublishinggroup.com/j/ajp doi: 10.11648/j.ajp.20200601.19 ISSN: 2472-0887 (Print); ISSN: 2472-0909 (Online) Perinatal Outcome in Hypertensive Disorder of Pregnancy - A Retrospective Study from a Tertiary Care Teaching Hospital Mustafa Captain, Sanjay Natu * , Sameer Mhatre, Anjali Parekh, Manas Kumar Behera Department of Paediatrics, Smt Kashibai Navale Medical College & General Hospital, Pune, India Email address: * Corresponding author To cite this article: Mustafa Captain, Sanjay Natu, Sameer Mhatre, Anjali Parekh, Manas Kumar Behera. Perinatal Outcome in Hypertensive Disorder of Pregnancy - A Retrospective Study from a Tertiary Care Teaching Hospital. American Journal of Pediatrics. Vol. 6, No. 1, 2020, pp. 52-57. doi: 10.11648/j.ajp.20200601.19 Received: January 22, 2020; Accepted: February 18, 2020; Published: February 26, 2020 Abstract: Hypertensive disorder of pregnancy (HDP) is a multisystem disorder of pregnancy known to jeopardize safe pregnancy thereby increasing the maternal and neonatal morbidity and mortality. A retrospective observational study of nine months duration was conducted to determine the fetal and early neonatal outcome in pregnancies complicated with HDP in a tertiary care hospital. Result: 163 women with HDP delivered during the study period. Out of total 163 births, perinatal deaths occurred in 18 (11.04%) cases, of which 10 (6.13%) were stillbirth and 8 (5.23%) were early neonatal death thus making a perinatal mortality rate of 110 per 1000 births. Low birth weight and preterm delivery occurred in 71 (43.56%) & 42 (25.77%) respectively. Amongst the 53 (32.52%) neonates who required admission to the NICU, 37 (69.8%) neonates had respiratory distress including 23 (43.4%) neonates’ requiring ventilatory support. Occurrences of adverse perinatal outcomes were significantly higher in eclampsia & preeclampsia as compared to gestational HTN except for metabolic abnormalities. Conclusion: There is a significant burden of perinatal mortality and morbidity more so with pre-eclampsia & eclampsia. The findings of this study can represent an evidence for healthcare providers and policy makers in devising more appropriate interventions for in utero transfer of women with HDP so as to improve perinatal outcomes. Keywords: Hypertensive Disorders of Pregnancy, Perinatal Morbidity, Perinatal Mortality 1. Introduction Hypertensive disorder of pregnancy (HDP) is one of the most common medical problems encountered in pregnancy [1, 2]. It is a multisystem disorder of pregnancy known to increase the maternal and neonatal morbidity and mortality, thus making it a significant global health issue [3, 4]. HDP occurs in about 10% of all pregnant women around the world [5]. The adverse perinatal outcomes associated with hypertensive disorders are generally referable to placental insufficiency, placental abruption, hypoxia and prematurity- related complications. Foetal complications are linked to the severity of preeclampsia and eclampsia. Perinatal mortality which includes stillbirth and early neonatal death are also seen to be increased HDP [6-8]. Perinatal mortality is a key indicator of maternal care and a reflection of the quality of obstetric and pediatric care available in a country. Global perinatal mortality rate (PMR) is estimated to be 47 per 1000 birth with excessively wide disparity between the developed and less developed regions [9]. Apart from perinatal mortality, significant neonatal morbidities in the form of low birth weight, intrauterine growth restriction (IUGR), preterm birth, respiratory distress requiring neonatal intensive care unit (NICU) admission are seen with greater frequencies in HDP. Similarly, long term morbidities in the form of developmental consequences are also known [10]. As compared to the literature on maternal outcomes in HDP, there is a relative dearth of data from Indian setting on