Kalaimathi et al Journal of Drug Delivery & Therapeutics. 2022; 12(1):102-108 ISSN: 2250-1177 [102] CODEN (USA): JDDTAO Available online on 15.01.2022 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research Copyright © 2022 The Author(s): This is an open-access article distributed under the terms of the CC BY-NC 4.0 which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited Open Access Full Text Article Research Article In-silico Absorption, Distribution, Metabolism, Elimination and Toxicity profile of Isopulegol from Rosmarinus officinalis R.V. Kalaimathi 1 , A. Jeevalatha 2 , A.N. Basha 1 , C. Kandeepan 1 , S. Ramya 3 , T. Loganathan 4 , R. Jayakumararaj 3 1 PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India 2 Department of Zoology, GTN College, Dindigul, TamilNadu, India 3 Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India 4 Department of Plant Biology and Plant Biotechnology, LN Government College (Autonomous), Ponneri - 601204, TN, India Article Info: ________________________________________ Article History: Received 17 December 2021 Reviewed 30 December 2021 Accepted 09 January 2022 Published 15 January 2022 ________________________________________ Cite this article as: Kalaimathi RV, Jeevalatha A, Basha AN, Kandeepan C, Ramya S, Loganathan T, Jayakumararaj R, In-silico Absorption, Distribution, Metabolism, Elimination and Toxicity profile of Isopulegol from Rosmarinus officinalis, Journal of Drug Delivery and Therapeutics. 2022; 12(1):102-108 DOI: http://dx.doi.org/10.22270/jddt.v12i1.5188 ________________________________________ *Address for Correspondence: R. Jayakumararaj, Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India Abstract ____________________________________________________________________________________________________ Plant Based Natural Products (PBNPs) have contributed to the development of many drugs for diverse indications. Worldwide interest in use of plants based natural products (PBNPs) has been growing, and its beneficial effects being rediscovered for the development of new drugs. Literature survey on indigenous traditional knowledge bestows ethnopharmacological potentials of PBNPs, which has inspired research in drug discovery; further it provides a baseline for the development of novel drug leads against selected pharmacological targets. Studies report that rosemary essential oil (ROEO) extracts have hepatoprotective, antifungal, insecticide, antioxidant and antibacterial properties. However, their application is limited because of their odor, color and taste. Owing to the widespread applications of phyto- compounds in ROEO - GCMS was performed. GCMS analysis detected 22 compounds of which 6 compounds were in abundant. In the present study, isopulegol - a Prenol Lipid (Monoterpenoid) from Rosmarinus officinalis has been ADMET characterized from biomedical application point of view. Keywords: Rosmarinus officinalis; Rosemary officinalis Essential Oils (ROEO); Pharmacological Activity; ADMET; GCMS; INTRODUCTION Rosmarinus officinalis L. (Rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world 1 . Besides, therapeutic application, it is commonly used as a condiment and preservative. R. officinalis is contains many bioactive molecules, phyto-compounds, endowed with pharmacological activities, such as anti-aging, anti-inflammatory, antioxidant, antimicrobial, anti- proliferative, antitumor, tumor-protective, tumor-inhibitory and attenuating activities 2 . Essential oils (EOs) a major group of phytogenic bioactive compounds (PBAC) have been used for variety of purposes over thousands of years. Due to their strong aromatic properties and bioactive nature, EOs has been used in aromatherapy, as flavor and fragrances in cosmetics, foods, and more recently as pharmaceuticals, natural preservatives, additives, and biopesticides 3 . EOs are concentrated form of liquid mixtures of volatile compounds of plant origin with unique structural chemistry including terpenoid and non-terpenoid hydrocarbons and their oxygenated derivatives, with natural color, odor and flavor, or “essence” of their source - volatile/ odoriferous oil. Essential oils are isolated from various plant components such as leaves, fruit, bark, root, wood, heartwood, gum, balsam, berries, seeds, flowers, twigs, and buds 4 . Role of PBNPs in drug development has been practiced and well documented since antiquity and recently increasing, not because the bioactive compounds are directly used as therapeutic agents but due to fact that they are used as raw material for drug synthesis, or as a base model for new biologically active compounds due to its GRAS nature 5-13 . As people are more concerned about the negative effect of synthetic chemicals in food, there is a need to find “GO”