Automatic Assessment of Clinical Frailty of Parkinson’s Disease Subjects Marcello C. Fusca 1 , Emanuela Riva 2 , Paolo Perego 1 , Francesca Omini 3 , Emanuele Conte 2 , Marco Impallomeni 2 , Stefania Rosaspina 2 , Antonio Grillo 2 , Suardi Teresa 2 , Stefano Fabbrini 2 , and Giuseppe Andreoni 1,4(B ) 1 Design Department, TeDH-SensibiLab, Politecnico di Milano, Milan, Italy giuseppe.andreoni@polimi.it 2 A.S.P. “Golgi-Redaelli”, Milan, Italy 3 Università degli Studi di Milano-Bicocca, Scuola di Specialità in Medicina Fisica e Riabilitativa, Milan, Italy 4 CNR, Institute of Molecular Bioimaging and Physiology - IBFM, Segrate (Milan), Italy Abstract. A wearable actigraph was applied in the functional assessment of sub- ject affected by Parkinson Disease in Day Hospital setting. 24 Parkinson Disease patients participated in this study. A set of standard functional tests (6-Minutes Walking Test, Timed-Up-and-Go test, 10-m and 50-m) were administered to col- lect data of functioning and physiatrist assigned the score according to the Clinical Frailty Scale. An automatic evaluation of this frailty score is proposed using data from 6-Minutes Walking Test and Timed-Up-and-Go test. The coherence of this automated classification method based on a basic summative linear equation of the 2 functional scores, is 66,7% with respect to the score assigned by skilled physi- atrists. The inclusion of the other data is expected to improve reliability and the possibility to have an automatic identification of the frailty level through quanti- tative data could open the possibility to have a more detailed assessment and even continuous and domiciliary follow ups. Our goal is to have a predictive tool for the patient’s state of frailty. Keywords: Clinical frailty scale · Wearable · Actigraphy · Parkinson’s disease · Functional assessment 1 Introduction Parkinson’s disease (PD) is a neurodegenerative disease of the central nervous system (CNS) with reduced levels of dopamine due to the degeneration of neurons in the sub- stantia nigra area. It is characterized by a progressive and chronic disorder, mainly concerning the control of movements and balance [1]. PD is characterized clinically by precise distinctive signs: © ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2021 Published by Springer Nature Switzerland AG 2021. All Rights Reserved P. Perego et al. (Eds.): ICWH 2020, LNICST 376, pp. 177–187, 2021. https://doi.org/10.1007/978-3-030-76066-3_14