Advances in Reproductive Sciences, 2019, 7, 31-38 http://www.scirp.org/journal/arsci ISSN Online: 2330-0752 ISSN Print: 2330-0744 DOI: 10.4236/arsci.2019.72005 May 10, 2019 31 Advances in Reproductive Sciences Are Acute Phase Reactants and CA125 Useful for Pregnancy Prediction in Frozen Embryo Transfer? Ayse Z. Ozdemir 1* , Cagri Gulumser 2 , Aysin Turkmen 1 , Davut Guven 1 , Pervin Karli 3 1 Ondokuz Mayıs University Hospital, Ondokuz Mayıs University IVF Center, Samsun, Turkey 2 Department of Obstetrics and Gynecology, University of Health Science, Istanbul, Turkey 3 Department of Obstetrics and Gynecology, Amasya University, Amasya, Turkey Abstract Objective: This study assessed blood C-reactive protein (CRP), fibrinogen, procalcitonin, and CA125 levels and determined whether they have an effect on pregnancy. Material & Methods: Between Feb. and Sep. 2018, 50 consec- utive women who had their first frozen embryo transfer at a tertiary referral IVF center in Turkey were included in the study. Serum samples were col- lected on the second day of the cycle and on the transfer day. The women were divided into two groups based on the results of pregnancy outcome: pregnant (group 1) and non-pregnant (group 2). Blood CRP, fibrinogen, procalcitonin, and CA125 levels were compared between the groups. Results: There were no statistically significant differences between the groups accord- ing to CA125, CRP, fibrinogen, and procalcitonin levels at the beginning of the cycle and on the transfer day. In comparison with levels at the beginning of the cycle and on the transfer day, fibrinogen and CRP were significantly higher on the transfer day than at the beginning of the cycle. Procalcitonin was significantly higher on the transfer day than at the beginning of the cycle in group 1. However, there was no statistically significant difference between the transfer day and the beginning of the cycle in group 2. Conclusions: However, the fibrinogen, CRP and procalcitonin levels were significantly higher on the transfer day than at the beginning of the cycle. The results in- dicated that acute phase reactants or CA125 should not be used to determine the time of embryo transfer or predict pregnancy. Keywords Procalcitonin, CRP, Fibrinogen, CA125, Embryo Transfer, Pregnancy How to cite this paper: Ozdemir, A.Z., Gulumser, C., Turkmen, A., Guven, D. and Karli, P. (2019) Are Acute Phase Reactants and CA125 Useful for Pregnancy Predic- tion in Frozen Embryo Transfer? Advances in Reproductive Sciences, 7, 31-38. https://doi.org/10.4236/arsci.2019.72005 Received: March 10, 2019 Accepted: May 7, 2019 Published: May 10, 2019 Copyright © 2019 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access