74 ORI GI NAL ARTI CLE ABSTRACT Aim: to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population. Methods: cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m 2 to <30 kg/ m 2 ) and obese class II (BMI >30 kg/m 2 ). Leptin, adiponectin and resistin level concentration were measured. Results: leptin concentration in obese class I was 13,998 ± 13,486 ng/ml; adiponectin was 3.98 ± 1.78 μg/ml; resistin were 25.676 ± 13.434 ng/ml. Leptin concentration in obese class II 31,074 ± 26,158 ng/ml; adiponectin 4,75 ± 1,88 μg/ ml; resistin 25,46 ± 12,26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.006)}. Adiponectin and resistin concentration was not significantly higher in obese class II than obese class I (p=0,156 and p=0,956). Conclusion: leptin concentration in obese class II was significantly higher than in obese class I but adiponectin and resistin were not different. Key words: leptin, adiponectin, resistin, obesity class I and II. Leptin, Adiponectin and Resistin Concentration in Obesity Class I and II at Sardjito Hospital Yogyakarta Hemi Sinorita, Rizka H. Asdie, R. Bowo Pramono, Luthfan B. Purnama, AH. Asdie Department of Internal Medicine, Faculty of Medicine, Gadjah Mada University - dr. Sardjito Hospital. Jl. Kesehatan Sekip no. 1, Yogyakarta. Correspondence mail to: hemisinorita@yahoo.com INTRODUCTION Adipocytes produce and secrete several proteins that act as veritable hormones, responsible for the regulation of energy intake and expenditure, known as adipocytokines. 1 Adipocytokines include leptin, adipsin, TNF-α, adiponectin and resistin. Their dysregulation now is known to be involved in the etiology of insulin resistance. Leptin affects energy homeostasis by inhibiting food intake and stimulating energy expenditure. Both leptin synthesis and circulating levels are increased in obese patients and are correlated with the fat mass in a chronic manner, most obese patients are leptin resistant. Adiponectin is inversely correlated with leptin, its plasma levels are significantly reduced in obese subjects, in insulin-resistant subjects, and in type 2 diabetic patients and increased after weight reduction. Two independent case-control studies in healthy caucasians and in Pima Indians indicate that low plasma adiponectin levels are associated with an increased risk of type 2 diabetes. 2-5 Resistin has been implicated in the pathogenesis of obesity-mediated insulin resistance and type II diabetes mellitus (T2DM). Human studies have highlighted increased resisitin expression in adipose tissue, particularly abdominal depots, furthemore, positive correlation beween serum resistin and body fat content has also been reported. 1,2,6-8 Studies have shown different concentration of leptin, adiponectin and resistin in obese and non obese patient. The aim of this study was to know different concentration of leptin, adiponectin and resistin in obesity class I and obesity class II. METHODS A cross-sectional study was conducted from June 2006 until January 2007 among 57 obese native Javanese patients suffering from type 2 diabetes and non diabetes