J Pharm Sci Bioscientific Res. 2016 6(2):182-186 ISSN NO. 2271-3681 Patel D. et al 182 Self-Emulsifying Drug Delivery System of Fenofibrate Dhaval Patel, Nishith K. Patel, Hardeep Banwait Department of Pharmaceutics and Pharmaceutical technology, A-One college of Pharmacy, Anasan, Ahmedabad, Gujarat, India ABSTRACT: In current study formulation of self emulsifying drug delivery system of Fenofibrate was carried out using Lipd phase, emulsifier and co emulsifier flax seed oil, tween 20 and polyethylene glycol 600 respectively. various oil, emulsifier and co emulsifiers were selected based on their solubility. Using water titration method ternary phase diagram ware prepared for SEDDS and emulsification region were analysed visually. All prepared formulations were evaluated for dilution studies, self emulsification time, drug content, in-vitro dissolution, droplet size determination, zeta potential measurement, viscosity determination and thermodynamic stability study. Based on stability study results, viscosity and usage of less emulsifier the final formulation were prepared. The comparison of invitro dissolution study of final formulation shows 5.4 fold and 1.8 fold increases in dissolution at 60 min with pure drug and marketed formulation respectively. KEYWORDS: Atorvastatin calcium, SEDDS, microemulsion based tablet, Liquid retention potential, Career: coat ratio. Article history: Received 10 April 2015 Revised 14 Sept 2015 Accepted 16 Jan 2016 Available online 01 March 2016 Citation: Patel D., Patel N., Banwait H. Self- Emulsifying Drug Delivery System of Fenofibrate. J Pharm Sci Bioscientific Res. 2016 6(2):182-186 *For Correspondence: Dhaval Patel Student of Pharmaceutics, A-One college of Pharmacy, Anasan, Ahmedabad, Gujarat, India. (www.jpsbr.org) INTRODUCTION: Fenofibrate is an anti-lipidemic agent which reduces both cholesterol and triglycerides in the blood. mainly used for primary hypercholesterolemia or mixed dyslipidemia. Fenofibrate appears to decrease the risk of cardiovascular disease and possibly diabetic retinopathy in those with diabetes mellitus. It also appears to be helpful in decreasing amputations of the lower legs in this same group of people 1 2 . It is used in addition to diet to reduce elevated low-density lipoprotein cholesterol (LDL), total cholesterol, triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL) in adults with primary hypercholesterolemia or mixed dyslipidemia. It is used in addition to diet for treatment of adults with severe hypertriglyceridemia. Self-emulsifying drug delivery systems (SEDDS) are isotropic mixture of oils, surfactant and co-solvents/ surfactant, which forms fine stable o/w emulsions, when introduced in the aqueous phase under condition of gentle agitation. The natural digestive motility of the stomach and intestine provides the agitation required for self-emulsification in vivo.15 16 The spontaneous formation of an emulsion upon release in the GI tract advantageously presents the drug in a dissolved form and the small droplets size provides a large interfacial surface area for drug absorption. Apart from solubilization, the presence of lipid in the formulation further helps improve