JPSBR: Volume 3, Issue 5: 2013 (151-157) ISSN NO. 2271-3681 Patel N. et al 151 ABSTRACT: Melt in mouth tablets are oral solid dosage form which when placed on tongue disintegrates rapidly, releasing the drug, which dissolves or disperses in the saliva and then swallowed with or without heat of saliva. Melt in Mouth tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. It is very important drug delivery system in case where drug absorbed from buccal cavity. Rapid disintegration of tablet cause quick dissolution and thus fast onset of action. It provides good stability, accurate dosing, easy manufacturing, reduced packaging size; self administration is possible during travelling as water is not required and easy to handle by patients. It is easy to administer for pediatric, geriatric, and institutionalized patients especially for uncooperative patients. KEYWORDS: Melt in Mouth, Rapid Melt, Mouth Dissolving, Oro Dispersible, buccal cavity. Melt In Mouth Tablet-A Futuristic Drug Delivery System Article history: Received 10 Oct 2013 Accepted 11Nov 2013 Available online 13 Nov 2013 For Correspondence: Mr. Nishith Patel A-One Pharmacy College Ahmedabad, Gujarat, India Email: nish11586@yahoo.com (www.jpsbr.org) INTRODUCTION Melt-in-mouth tablets (MMT) can be defined as an oral solid dosage form which when placed on tongue disintegrates rapidly, releasing the drug, which dissolves or disperses in the saliva and then swallowed. Some drugs are absorbed from the mouth, pharynx, and esophagus as the saliva passes down in to the stomach. 1, 2 The drug having molecular size between 75-600 Daltons, molecular weight between 200-500 Daltons, stable at buccal pH and are either lipophilic or hydrophilic in nature will be easily absorbed from the buccal mucosa. 3 The tablet is the most widely used dosage form because its convenience in terms of compactness, self administration and also in manufacturing. Patients are like Pediatric, geriatric experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. To overcome this weakness scientists have developed innovative drug delivery system which known as “Melt in Mouth “Fast Dissolve”, “Rapid Melt”, “Quick Disintegrating”, “Mouth Dissolving” “Orally disintegrating”, “Oro Dispersible” are the terms that represents same Drug delivery system. 4, 5, 6 These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. According to European Pharmacopoeia, the MMT should disperse or disintegrate in less than three minutes. Nishith Patel*, Yashesh Shashtri Department of Pharmaceutical Technology, A-One Pharmacy College, Ahmedabad, Gujarat, India