Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2013, 5(9):34-39 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 34 Antihyperglicemic activity of some chromium(III)-amino acid complexes in nicotinamide-streptozotocin induced diabetic wistar rats Kun Sri Budiasih 1 *, Chairil Anwar 2 , Sri Juari Santosa 2 , Hilda Ismail 3 and Ika Puspita Sari 3 1 Chemistry Education Dept, Faculty of Mathematics and Natural Sciences, Yogyakarta State University, Indonesia 2 Chemistry Dept, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia 3 Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia _____________________________________________________________________________________________ ABSTRACT Investigation of an in vivo application of chromium- amino acid complexes was conducted on nicotinamide- streptozotocin induced diabetic Wistar rats. The rats were divided into 9 groups each consist of 4 animals. Three groups are control (+) with chromium picolinate (CrPic), control (-)diabetic group (DM) and control non diabetic (non DM). Furthermore, three groups wereexamined on the effect of Formula A (Cr-glutamate by 1:3 ratio)at dose (100, 200 and 400 μg/day). In addition, the last 3 groups were studied on the effect of different formula of Cr (III)- glutamato made of Cr-glutamate by ratio 1:2 (200 μg/day), Cr-glycine (1:3) and Cr-cysteine(1:3) complexes. The blood glucose levels were measured before and after treatment. All formulas gave significant effect in lowering glucose level (p 0.05) compared to diabetic rats control group. Keywords: Antihiperglycemic, amino acid, chromium,complexes, nicotinamide-streptozotocin. _____________________________________________________________________________________________ INTRODUCTION Diabetes is a metabolic disease which characterized by hyperglycemia and glycosuria resulting from the defect of the secretion or the action of insulin, or both of them. Prediction of the World Health Organization (WHO) explained that the amount of diabetic patients in Indonesia will increase from 8.4 million at 2000 to 21.3 million in 2030. International Diabetes Federation (IDF) also predicted the similar condition. Prevalence of diabetes mellitus in Indonesia is 5.7% at 2010 [1,2]. Diabetes currently affects more than 194 million people worldwide and is expected to reach 333 million by 2025,with the maximum burdens falling upon developing countries [3]. Diet, exercise, supplement or nutraceutical, oral hypoglycemic agents and insulin are the particular management of diabetes. Nutraceuticals (often referred to functional foods) are natural bioactive or chemical compounds that have health promoting, disease preventing or medicinal properties [4].Some natural product were used as antidiabetic or hypoglycemic agent, for example Raphanus Sativus L. Leaves [5], Allium Cepa, L,[6] andCocos nusifera I [7]. Most nutraceutical usually come from organic compounds. The research on inorganic nutraceutical is less popular. Inorganic compound or metal-containing medicinal product may contain one of these probabilities: (a) chemical elements essential to life forms, for example, iron for anemia (b) non essential/toxic elements that carry out specific medicinal purposes, for example platinum as antitumor agents[8].