Annals of Clinical and Analytical Medicine 1 Annals of Clinical and Analytical Medicine Original Research Yalçın Karagöz 1 , Mustafa Tosun 2 1 Department of Health Management, Business Faculty, Düzce University, Düzce 2 Department of Dermatology, Medicine Faculty, Sivas Cumhuriyet University, Sivas, Turkey The efect of isotretinoin use Efect of isotretinoin use on hematological parameters and biochemical values DOI: 10.4328/ACAM.20921 Received: 2021-10-26 Accepted: 2021-11-09 Published Online: 2021-11-15 Corresponding Author: Mustafa Tosun, Dermatology Department, School of Medicine, Sivas Cumhuriyet University, 58140, Sivas, Turkey. E-mail: mustafatosun@cumhuriyet.edu.tr P: +90 544 607 29 16 Corresponding Author ORCID ID: https://orcid.org/0000-0002-6189-8016 Abstract Aim: The aim of this study was to investigate the general efects of oral isotretinoin on hematological parameters and biochemical values, and to identify whether these values vary according to age and gender. Material and Methods: The study included 143 patients diagnosed with moderate or severe acne in the age range of 15-47 years. Patients were monitored retrospectively. Hematological parameters and biochemical values were recorded before treatment, then at the end of the frst and third months of the treatment. Results: The serum lipid levels, creatinine, cholesterol, triglyceride and AST values of liver enzymes, and renal function values were found to increase afer the onset of treatment. Hematological parameters including LYM, HGB, HCT, RDW, MCV, PLT, MPV and PCT parameters were seen to increase afer the onset of treatment, while the NEU parameter decreased. The values of other hematological parameters did not change. Discussion: Although the use of oral isotretinoin has been shown to cause changes in hematological parameters and serum lipid levels, liver and renal function values, these changes usually remain within normal limits and continue with treatment. Keywords Isotretinoin, Acne, Hematological Parameters, Biochemical Values This study was presented orally at the XXIV. Prof. Dr. Lütfü Tat Symposium (Oral Presentation), 2019, Ankara, Turkey