1 Baricitinib restrains the immune dysregulation in COVID-19 patients Vincenzo Bronte 1, *, Stefano Ugel 1, *, Elisa Tinazzi 2 , Antonio Vella 1 , Francesco De Sanctis 1 , Stefania Canè 1 , Veronica Batani 1 , Rosalinda Trovato 1 , Alessandra Fiore 1 , Varvara Petrova 1 , Francesca Hofer 1 , Roza Maria Barouni 1 , Chiara Musiu 1 , Simone Caligola 1 , Laura Pinton 1 , Lorena Torroni 3 , Enrico Polati 4 , Katia Donadello 4 , Simonetta Friso 2 , Francesca Pizzolo 2 , Manuela Iezzi 5 , Federica Facciotti 7 , Piergiuseppe Pelicci 7 , Daniela Righetti 8 , Paolo Bazzoni 8 , Mariaelisa Rampudda 8 , Andrea Comel 8 , Walter Mosaner 8 , Claudio Lunardi 2 and Oliviero Olivieri 2 . 1 Immunology Section, Department of Medicine, University and Hospital Trust of Verona, 37134 Verona, Italy. 2 Internal Medicine Section B Section, Department of Medicine, University and Hospital Trust of Verona, 37134 Verona, Italy. 3 Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, 37134 Verona, Italy. 4 Intensive Care Unit, Department of Surgery, Dentistry, Maternity and Infant, University and Hospital Trust of Verona, 37134 Verona, Italy. 5 Intensive Care Unit, Department of Surgery, Dentistry, Maternity and Infant, University and Hospital Trust of Verona, 37134 Verona, Italy. 6 CAST- Center for Advanced Studies and Technology, University of G. D’Annunzio of Chieti-Pescara, 66100 Chieti (CH), Italy. 7 Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy 8 Pederzoli Hospital, 37019 Peschiera sul Garda, Italy *denotes equal contribution Corresponding author. Prof. Vincenzo Bronte Immunology Section, Department of Medicine University and Hospital Trust of Verona phone: +390458124007 fax: +390458126455 vincenzo.bronte@univr.it Conflict of interest The authors declare no competing interests. All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 30, 2020. ; https://doi.org/10.1101/2020.06.26.20135319 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.