iScience Article Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion Zn 2+ intoxication of Cg fungal fitness ROS fungal fitness Zn 2+ Candida glabrata (Cg) Phagolysosome type I interferons ROS Zn 2+ Metallothioneins Zn 2+ sequestration of Cg dead Cg Michael Riedelberger, Philipp Penninger, Michael Tscherner, ..., Gernot Schabbauer, Guenter Weiss, Karl Kuchler karl.kuchler@meduniwien.ac. at HIGHLIGHTS Metallothioneins shuttle zinc into macrophage phagosomes to elicit pathogen killing Zinc sequestration by metallothioneins drives potent fungicidal ROS responses IFN-I signaling dysregulates host zinc homeostasis during invasive candidiasis IFNs-I suppress zinc intoxication and promote pathogen fitness and immune evasion Riedelberger et al., iScience 23, 101121 May 22, 2020 ª 2020 The Author(s). https://doi.org/10.1016/ j.isci.2020.101121 ll OPEN ACCESS