Editorials Maintenance therapy in advanced colorectal cancer, yes or no? Ask the laboratory A. Sobrero & A. Damiani 2043 Metastasis of cancer: when and how? W.-C. Lee, S. Kopetz, I. I. Wistuba & J. Zhang 2045 Revival of PI3K inhibitors in non-Hodgkin’s lymphoma C. L. Batlevi & A. Younes 2047 Proton therapy in mediastinal Hodgkin lymphoma: moving from dosimetric prediction to clinical evidence U. Ricardi, B. Dabaja & D. C. Hodgson 2049 The Italian Collaborative Group sets a standard for the treatment of locally advanced head and neck cancer K. Misiukiewicz, V. Gupta & M. Posner 2051 Chemotherapy-induced toxicity—a secondary effect caused by released DNA? T. Helleday 2054 Treating cancer cachexia: an evolving landscape B. Laird & M. Fallon 2055 Special article The ‘critical mass’ survey of palliative care programme at ESMO designated centres of integrated oncology and palliative care D. Hui, N. Cherny, N. Latino & F. Strasser 2057 Reviews Borderline resectable pancreatic cancer: conceptual evolution and current approach to image-based classification J. W. Gilbert, B. Wolpin, T. Clancy, J. Wang, H. Mamon, A. B. Shinagare, J. Jagannathan & M. Rosenthal 2067 How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials F. Bonnetain, C. Borg, R. R. Adams, J. A. Ajani, A. Benson, H. Bleiberg, B. Chibaudel, E. Diaz-Rubio, J. Y. Douillard, C. S. Fuchs, B. J. Giantonio, R. Goldberg, V. Heinemann, M. Koopman, R. Labianca, A. K. Larsen, T. Maughan, E. Mitchell, M. Peeters, C. J. A. Punt, H. J. Schmoll, C. Tournigand & A. de Gramont 2077 International cancer seminars: a focus on esophageal squamous cell carcinoma G. Murphy, V. McCormack, B. Abedi-Ardekani, M. Arnold, M. C. Camargo, N. A. Dar, S. M. Dawsey, A. Etemadi, R. C. Fitzgerald, D. E. Fleischer, N. D. Freedman, A. M. Goldstein, S. Gopal, M. Hashemian, N. Hu, P. L. Hyland, B. Kaimila, F. Kamangar, R. Malekzadeh, C. G. Mathew, D. Menya, G. Mulima, M. M. Mwachiro, A. Mwasamwaja, N. Pritchett, Y.-L. Qiao, L. F. Ribeiro-Pinto, M. Ricciardone, J. Schu ¨z, F. Sitas, P. R. Taylor, K. Van Loon, S.-M. Wang, W.-Q. Wei, C. P. Wild, C. Wu, C. C. Abnet, S. J. Chanock & P. Brennan 2086 Unmet needs in the first-line treatment of follicular lymphoma C. Casulo, L. Nastoupil, N. H. Fowler, J. W. Friedberg & C. R. Flowers 2094 Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy F. Bozzetti 2107 Original articles Preclinical and experimental science Prevention of chemotherapy toxicity by agents that neutralize or degrade cell-free chromatin I. Mittra, K. Pal, N. Pancholi, A. Shaikh, B. Rane, P. Tidke, S. Kirolikar, N. K. Khare, K. Agrawal, H. Nagare & N. K. Nair 2119 Continued overleaf Annals of Oncology Official Journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology Volume 28 | No. 9 | September 2017