Dynamic Aortic Aneurism Risk Factors Oleg METSKER a ,1 , Georgy KOPANITSA b , Olga IRTYUGA a , Vladimir USPENSKIY a a Almazov National Medical Research Centre, Saint-Petersburg, Russia b ITMO University, Saint-Petersburg, Russia Abstract. According to different systematic reviews incidence of thoracic aortic aneurysms (TAA) in the general population is increasing in frequency ranging from 5 to 10.4 per 100000 patients. However, only few studies have illustrated the role of different risk factors in the onset and progression of ascending aortic dilatation. Currently, noninvasive imaging techniques are used to assess the progression rate of aortic and aortic valve disease. Transthoracic (TT) Echocardiographic examination routinely includes evaluation of the aorta It is the most available screening method for diagnosis of proximal aortic dilatation. Since the predominant area of dilation is the proximal aorta, TT-echo is often sufficient for screening. We retrospectively analyzed the ECHO database with 78499 echocardiographic records in the Almazov National Medical Research Centre to identify patients with aneurysm. Detailed information including demographic characteristics, ECHO results and comorbidities were extracted from outpatient clinic and from hospital charts related to hospitalizations occurring within a year before index echocardiography was performed. Comorbid diseases were similarly extracted from outpatient clinic and/or hospital admissions. The classifier showed an AUC-ROC for predicting of aneurism detection after a repeated ECHO at 82%. Keywords. Aneurism, Machine learning, risk factor, prognosis 1. Introduction Non-coronary heart diseases are a large heterogeneous group of diseases [1]. Given their prevalence and mortality in the general population, they have an important medical and social significance. We have chosen aortic valve and ascending aorta diseases as a model of non-coronary heart disease. These diseases are diagnosed most late due to the absence of clinical symptoms before the onset of complications up to lethal outcomes. According to different systematic reviews incidence of thoracic aortic aneurysms (TAA) in the general population is increasing in frequency ranging from 5 to 10.4 per 100000 patients [2,3]. However, only few studies have illustrated the role of different risk factors in the onset and progression of ascending aortic dilatation [4,5] Currently, noninvasive imaging techniques are used to assess the progression rate of aortic and aortic valve disease [6]. Transthoracic (TT) Echocardiographic examination routinely includes evaluation of the aorta. It is the most available screening method for diagnosis of proximal aortic dilatation. Since the predominant area of dilation is the proximal aorta, TT-echo is often sufficient for screening [7,8]. 1 Corresponding Author, Georgy Kopanitsa, ITMO University, Saint-Petersburg, Russia, E-mail: georgy.kopanitsa@gmail.com pHealth 2021 B. Blobel and M. Giacomini (Eds.) © 2021 The authors and IOS Press. This article is published online with Open Access by IOS Press and distributed under the terms of the Creative Commons Attribution Non-Commercial License 4.0 (CC BY-NC 4.0). doi:10.3233/SHTI210585 130