J Skin Stem Cell. 2020 December; 7(4):e116498. Published online 2021 July 17. doi: 10.5812/jssc.116498. Research Article Evaluation of Reliability and Validity of Persian Version of Children’s Dermatology Life Quality Index (CDLQI) Questionnaire and Practical Use Saman Mohammadi 1 , Maryam Khalili 1 , Saeedeh Farajzadeh 1 , Hossein Safizadeh 2 , Rezvan Amiri 1 , Mahin Aflatoonian 1, * and Salilah Shahabi 1 1 Leishmaniosis Research Center, Kerman University of Medical Sciences, Kerman, Iran 2 Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran * Corresponding author: Leishmaniosis Research Center, Kerman University of Medical Sciences, 761614111, Kerman, Iran. Email: maaflatoonian@gmail.com Received 2021 May 24; Revised 2021 June 21; Accepted 2021 June 26. Abstract Background: Atopic dermatitis is a common skin disease in children. Severe pruritus and eczematous lesions may interfere with the quality of life of the patients. Objectives: This study was designed to assess the validity and reliability of the Persian version of the children’s dermatology life quality index questionnaire. Methods: After obtaining final acceptance by the first developers of the questionnaire for developing a Persian version, it was dis- tributed to 100 children affected with atopic dermatitis aged 5 to 15 years. We analyzed data by SPSS18. Then, we evaluated the validity and reliability of the questionnaire by Kaiser criterion and Cronbach’s alpha. Results: Questions number 1 (itching) and 6 (sports activities) achieved the highest and the lowest scores, respectively. Cronbach’s alpha was assessed as 0.87, demonstrating good reliability. Inter-item correlation coefficients ranged from 0.24 to 0.69. A one-factor structure was achieved by Kaiser criterion and scree plot. Conclusions: Our study demonstrated good reliability and validity of the Persian version of the children’s dermatology Life Quality Index Questionnaire. There was a significant positive relationship between the severity of the disease and the score of quality of life. However, there was no relationship between the quality of life and the demographic features of the participants. Keywords: Reliability, Validity, CDLQI, Persian 1. Background Atopic dermatitis (AD) is a chronic and relapsing in- flammatory skin disease with more prevalence in children less than five years old (1). In one study in Kerman by Fara- jzadeh et al., the prevalence of AD was estimated at 9.1% (2). Genetic defects in epidermal structures and impaired skin barriers may lead to dry and irritable skin in these patients. Severe itching and eczematous lesions are key features of the disease. The acute phase of AD is defined by erythema, swelling, bulla, and vesicle formation, while the chronic phase is characterized by scaling and marked skin thick- ness (1-3). Former studies revealed that AD children have a lower quality of life (QoL) than those with other chronic diseases such as diabetes mellitus, epilepsy, renal disease, acne, pso- riasis, and vitiligo (4). Severe pruritus in patients with AD can result in anxiety, sleepiness, and low concentra- tion during daytime and negative effects on school perfor- mance (5, 6). Moreover, various factors such as air pollu- tion, house dust mite, and smoking can exacerbate or trig- ger the disease course (7, 8). Changes in lifestyle including hobbies, physical activities, dressing, and eating habits can interfere with the inter-personal and social relationships (9). Currently, there are different questionnaires to evalu- ate QoL in children with chronic disease (10-12). The English version of the Children’s Dermatology Life Quality Index (CDLQI) questionnaire exclusively evaluates QoL in chil- dren aged 4 to 16 years old. Atopic dermatitis is the most common skin disease evaluated by this questionnaire. The validity and reliability of different language versions of the questionnaire have already been evaluated (13). Copyright © 2021, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.