International Journal of Research in Medical Sciences | June 2016 | Vol 4 | Issue 6 Page 2246 International Journal of Research in Medical Sciences Kumar D et al. Int J Res Med Sci. 2016 Jun;4(6):2246-2251 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Research Article The spectrum of mild cognitive impairment in dyslipidemic non-elderly type 1 diabetics Deepak Kumar*, Veer Bahadur Singh, Babulal Meena, Sanjay Beniwal, Kulvinder Singh, Shivani Sidana, Rahul singla INTRODUCTION The worldwide prevalence of diabetes has risen dramatically over the past two decades, from an estimated 30 million cases in 1985 to 382 million in 2013. Based on current trends, the International Diabetes Federation projects that 592 million individuals will have diabetes by the year 2035. 1 In India, about 50.9 million people suffer from diabetes, and this figure is likely to go up to 80 million by 2025, making it the Diabetes Capital of the world. 2 Mild cognitive impairment (MCI, also known as incipient dementia, or isolated memory impairment) is a brain function syndrome involving the onset and evolution of cognitive impairments beyond those expected based on ABSTRACT Background: Diabetics often have reduced performance in numerous domains of cognitive function, a process termed as Diabetic encephalopathy. The exact pathophysiology of cognitive dysfunction in diabetes is not completely understood, but it is likely that hyperglycaemia, vascular disease, hypoglycemia, and insulin resistance play significant roles. Although cognitive dysfunction is quite common in elderly, however, its occurrence in non-elderly diabetics is not much investigated. Aim of the study was to identify the correlation among various components of lipid profile with mild cognitive impairment in non-elderly type 1 diabetics. Methods: 98 type 1 diabetics were enrolled justifying relevant inclusion &exclusion criteria. Anthropometric indices, biochemical and clinical parameters were measured. MoCA test was employed for the assessment of cognitive dysfunction. Receiver operating characteristic, partial correlation, and logistic regression analyzes were employed for evaluation. Results: 71.42% of enrolled diabetics had some degree of cognitive dysfunction. Duration of the disease had a significant impact on cognitive functioning (p=0.032).Gender, residential area as well as the age of onset of diabetes appeared to have an insignificant impact on cognitive functioning (p>0.05). Diabetics with poor glycemic control were more prone to develop MCI (p<0.001).On comparison of various component of MoCA test; it was seen that most significant parameter that was affected was attention (p<0.001), followed by delayed recall /memory, naming and abstraction (p<0.05). Conclusions: The results of our study suggest that dyslipidemia chiefly raised total cholesterol, triglycerides and LDL is quite common in non-elderly type 1 diabetics and are associated with poorer cognitive function. Cognitive dysfunction should be listed as one of the many complications of diabetes, along with retinopathy, neuropathy, nephropathy, and cardiovascular disease in the future. Keywords: Mild cognitive impairments, Dementia, Type 1 diabetes, Non elderly diabetics Department of Medicine, Sardar Patel Medical College, Bikaner Rajasthan, India Received: 09 April 2016 Accepted: 09 May 2016 *Correspondence: Dr. Deepak Kumar, E-mail: dr.deepak.2786@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161794