Sumatera Medical Journal (SUMEJ) Vol. 4, No. 1, 2021 | …… - …… SUMEJ Sumatera Medical Journal *Corresponding author at: Sumatera Utara University College of Medicine, Medan, Indonesia E-mail address: yongkywijaya198@gmail.com Copyright © 2021 Published by Talenta Publisher, ISSN: 2622-9234 e-ISSN: 2622-1357 Journal Homepage: http://smj.usu.ac.id C-Reactive Protein and Leukocyte as Predictors of Complications in Peripheral Arterial Disease Yongky Wijaya 1* , Riri Andri Muzasti ,2 1,2, Sumatera Utara University College of Medicine, Division Nephrology-Hypertension, Department of Internal Medicine Abstract. Peripheral Arterial Disease (PAD) is the narrowing of peripheral blood vessels which prevalence is high in the elders. In 2010, it was estimated that 202 million people were suffering from PAD, most of which are in developing countries, especially the Southeast Asia region. Inflammation markers such as leukocyte and C-Reactive Protein (CRP) can predict the incidence of PAD but their use in determining prognosis remains unclear. Complications in PAD include amputation, increased cardiovascular events, and even death. Aim: This study aims to determine the relationship between leukocyte and CRP level on complications in PAD, in the forms of amputation, cardiovascular events, and mortality. Methods: This is a meta analysis study which uses online literature sourced from Pubmed, Science Direct, Cochrane, and Google Scholar. Results: Based on the data analysis, there is a significant relationship between CRP with the incidence of amputation (HR 1.24, 95%CI: 1.02-1.49, p=0.03) and hs-CRP with cardiovascular events (HR 1.33, 95%CI: 1.10-1.60, p=0.003). Leukocyte on the other hand shows no significant relationship with the incidence of amputation (OR 1.10, 95%CI: 0.98-1.23, p=0.10) and mortality (OR 1.14, 95%CI: 0.97-1.35, p=0.12) Keyword: Peripheral Arterial Disease, Complication, Leukocyte, C-Reactive Protein Received 09 December 2020 | Revised 05 January 2021 | Accepted 13 January 2021 1 Introduction PAD is defined as partial or total narrowing of blood vessels in peripheral arteries which is most often caused by atherosclerosis 1 . The location of the obstruction is often found in the lower extremities, affecting the popliteal artery, femoral artery and aortoiliac artery. There are several risk factors for PAD which include diabetes, hypertension, smoking, obesity, alcohol use, race, and Chronic Kidney Disease (CKD). Other important factors are increase in leukocyte, homocysteine, fibrinogen, and C-Reactive Protein levels 2 . As many as 202 million people worldwide experienced PAD in 2010 and in the study A Global Atherothrombosis Assessment by American Society of Cardiology in 2006, it was found that the prevalence of PAD in Indonesia was 9.7%. A multi-country study of Peripheral Arterial Disease – Screening and Evaluation of diabetic patients in Asian Regions Characterized by