Int.J.Curr.Microbiol.App.Sci (2020) 9(3): 2440-2444 2440 Original Research Article https://doi.org/10.20546/ijcmas.2020.903.279 Therapeutic management of Ehrlichiosis in German Shepherd Dog: A Case Reports Y. P. Maheshwarappa*, Shivanagouda S Patil, C. R. Swapna, M. Chandrashekarappa, A. M. Kotresh and B. S. Pradeep *Corresponding author ABSTRACT Introduction Tick-borne diseases represent a problem of growing importance for public health (Parola et al., 2000). Ehrlichia canis is an obligate intracellular rickettsial agent that is transmitted by a brown dog tick i.e. Rhipicephalus sanguineus which is considered as the principal vector of this disease. ( Ristic and Holland, 1993). The disease is characterized by a wide variety of clinical signs of which depression, lethargy, weight loss, anorexia, pyrexia, lymphadenomegaly, splenomegaly, and bleeding tendencies are the most common. Major hematologic abnormalities comprise of thrombocytopenia, mild anemia, and mild leukopenia during the acute stage, mild thrombocytopenia in the subclinical stage, and pancytopenia in the severe chronic stage. The main biochemical abnormalities include hypoalbuminemia, hyperglobulinemia, and hypergammaglobulinemia (Harrus et al., 1997). International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 3 (2020) Journal homepage: http://www.ijcmas.com A 3-year-old male German Shepherd dog weighing 26 kg is presented to Referral Veterinary Polyclinic and Teaching Veterinary Clinical Complex, ICAR- IVRI, Izatnagar, with the history of reduced food intake, dullness, weakness in all limbs since 1 week, edema of the scrotum and all limbs since 3 days. Clinical examination revealed elevated rectal temperature- 104.30 F, tachycardia, increased respiratory rate, pale mucous membrane along with ticks over the body was noticed. Haematological examination showed decreased RBC count-1.93million/cmm, Leucocyte count- 8100/cmm, Neutrophils-75.6%, lymphocyte count-20.6%, Monocyte count- 3.8%, decreased HB- 4.9g%, Thrombocytopenia-80000/microlitre. Serum biochemistry has shown normal Creatinine value-1.1mg/dl and elevated SGPT value-218 IU/L. On blood smear examination with Giemsa staining, Ehrlichia Morulae were noticed in Monocytes suggestive of Canine Ehrlichiosis. Keywords edema of the scrotum and all limbs food intake, dullness Accepted: 20 February 2020 Available Online: 10 March 2020 Article Info