1 TITLE: Prolonged activity of factor IX as a monomeric Fc fusion protein RUNNING TITLE: Long lasting recombinant factor IX-Fc Authors: Robert T. Peters, 1 Susan C. Low, 1* George D. Kamphaus, 1 Jennifer A. Dumont, 1 John V. Amari, 1 Qi Lu, 1 Greg Zarbis-Papastoitsis, 1† Thomas J. Reidy, 1 Elizabeth P. Merricks, 2 Timothy C. Nichols, 2 and Alan J. Bitonti 1 1 Biogen Idec Hemophilia, Waltham, MA 2 Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC Corresponding Author: Robert T. Peters, Ph.D Director, Molecular and Cell Biology Biogen Idec Hemophilia 9 Fourth Avenue Waltham, MA 02451 Tel: 781-547-5297 Email: robert.peters@biogenidec.com Fax: 781-547-6008 *current affiliation: BIND Biosciences, Cambridge, MA †current affiliation: Percivia, LLC, Cambridge, MA Category for publication: Thrombosis and Hemostasis Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-08-239665 Copyright © 2010 American Society of Hematology For personal use only. on October 31, 2017. by guest www.bloodjournal.org From