DOI: 10.18410/jebmh/2015/960 ORIGINAL ARTICLE J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 41/Oct. 12, 2015 Page 7032 ETIOLOGICAL PROFILE OF NEW ONSET SEIZURES S. M. Saifullah Quraishi 1 , P. S. Usha Rani 2 , P. Prasanthi 3 , P. Sudhakar 4 HOW TO CITE THIS ARTICLE: S. M. Saifullah Quraishi, P. S. Usha Rani, P. Prasanthi, P. Sudhakar. “Etiological Profile of New Onset Seizures”. Journal of Evidence based Medicine and Healthcare; Volume 2, Issue 41, October 12, 2015; Page: 7032-7044, DOI: 10.18410/jebmh/2015/960 ABSTRACT: Seizures are common disorders found all over the world and are encountered frequently during medical practice in variety of settings. Presently CNS infections like malaria, meningitis, tuberculosis, HIV, Neurocysticercosis account for significant number of cases in developing countries. Since these infections vary from region to region; etiology of seizure may also vary from region to region. Etiological spectrum of acute symptomatic seizures in developing countries is different from developed countries. So this study was done to know the various etiologies of new onset seizures in adults in this region. Sample size taken for the study is 50 patients with new onset seizures. It is concluded that etiological spectrum of seizures was varied and included Neuroinfection, CVA, idiopathic, alcohol withdrawal, Tumor, Metabolic. Tuberculoma and neurocysticercosis are most common cause of seizure among Neuroinfection. INTRODUCTION: Seizures are common disorders found all over the world and are encountered frequently during medical practice in variety of settings. Etiological spectrum of acute symptomatic seizures in developing countries is different from developed countries. Presently CNS infections like malaria, meningitis, tuberculosis, HIV, neurocysticercosis account for significant number of cases in developing countries. [1] Since these infections vary from region to region; etiology of seizure may also vary from region to region. In Indian subcontinent cerebral venous thrombosis is common in postpartum women presents with severe headache, low-grade fever and seizures. [2] Seizures occur in about 40 percent of the patients, which is higher when compared to arterial stroke. Focal seizures are more common but they can generalize to a life-threatening status epilepticus. [3] Etiology of seizures can be easily made out in most of the older patients. The causes include subdural hematoma, stroke, CNS infections, degenerative disorders like Alzheimer’s disease and malignancy which includes malignant gliomas, and brain metastases [4]. In stroke seizures occur more commonly with hemorrhagic stroke than with ischemic stroke. They also can occur with systemic metabolic conditions like uremia, hyperglycemia, hypoglycemia, hyponatremia and alcohol withdrawal. So this study is done to know the various etiologies of new onset seizures in adults in this region. With the advent of modern technologies like CT scan, MRI and CSF serology for infection like viral, tubercular, neurocysticercosis, the diagnosis of seizure has become more accurate and has completely changed the course of management. AIMS AND OBJECTIVES OF THE STUDY:  To study the etiology of new onset seizures in adults in KURNOOL region in Andhra Pradesh, where there is increased incidence of infections.