Journal of International Dental and Medical Research ISSN 1309-100X Steroid Profile of Saliva http://www.jidmr.com Zurab Khabadze and et al Volume ∙ 14 ∙ Number ∙ 1 ∙ 2021 Page 344 Actuality of Studying the Steroid Profile of Saliva in the Planning of Dental Implantation Zurab Khabadze 1 , Julia Generalova 1 , Artemy Nedashkovsky 1 , Meri Sheroziia 1 , Kristina Hrytsenko 1 , Khadizhat Omarova 2 , Mariya Balashova 1 , Oleg Mordanov 1 * 1. RUDN University, Moscow, Russia. 2. Dagestan State Medical University, Makhachkala, Russia. Abstract The aim of this review is to analyze the value of determining saliva steroid profile for diagnosis of various conditions and diseases. Steroid hormones, due to their high lipophilicity, quite easily pass from the blood to the saliva. Saliva steroids can reflect the concentration in plasma of a free fraction of hormones, that is, non-conjugated with proteins. During a systematic review of the literature, publications were considered in the electronic databases Google Scholar and PubMed, the main concept of which was to study the steroid profile of saliva and its diagnostic significance. 56 publications were initially studied, of which 39 were included in the review after analysis by exclusion criteria. The study of saliva steroid profile is an appropriate technique, which can confirm some diagnoses, such as Cushing's syndrome. At the same time, it is necessary to keep in mind the limitations imposed by the saliva itself as a biomatrix due to the variability of its composition and cross sensitivity of components to certain reagents. Review (J Int Dent Med Res 2021; 14(1): 344-349) Keywords: Steroid profile, saliva, saliva steroids. Received date: 27 November 2020 Accept date: 27 December 2020 Introduction The human body is a dynamic open system, and, in its regulation, the endocrine system takes not the last place, which performs its work through the secretion of certain hormones. In various pathophysiological conditions and diseases disorders of organ activity is possible due to excessive/insufficient release of certain hormones. The group of steroid hormones, including sex hormones, glucocorticoids, mineralocorticoids and cardiotonic steroids, is widespread in terms of the number of target organs and their effects 1-4 . These substances, in particular, their quantity, are measured in clinical practice for the purpose of diagnosing pathologies and planning the further structure of the endocrine diseases treatment. Laboratory analysis can be subjected to completely different in composition and characteristics biological substrates: plasma and blood serum, urine and others 6,7,8 . Now, saliva is a promising matrix for calculating concentrations of steroids and some other biologically active substances in terms of laboratory diagnostics 7-11 . The technique of saliva sampling is not particularly difficult, it is non- invasive and short in time, allows to get several samples in a short period of time, which facilitates the process of obtaining a sample for the patient, since the procedure is painless and does not lead to excessive excitement, stress. Also, the procedure does not require special training of both medical personnel and the patient, as well as equipment 9-12 . Salivary steroids can reflect the levels of free circulating in blood steroids, that are not bound to some types of proteins. These nonconjugated hormones make up about 2 to 10% of their total content. During the analysis for the saliva steroid profile it is possible to suspect or confirm the presence of kidney pathologies, for example, chronic renal failure, adrenal glands, and genital glands 7,12,13 . The purpose of this review article is to determine the relevance of steroid hormones *Corresponding author: Oleg Mordanov RUDN University, Moscow, Russia. E-mail: mordanov19@gmail.com