*Correspondence: abdulillah1@yahoo.com (Received: 02 September 2019; accepted: 06 December 2019) Citaton: Abdulilah Saleh Ismaeil and Fraidoon A. Saleh, Sumac (Rhus coriaria L) as Quorum Sensing Inhibitors in Staphylococcus aureus, J Pure Appl Microbiol., 2019; 13(4):2397-2404. htps://doi.org/10.22207/JPAM.13.4.56 © The Author(s) 2019. Open Access. This artcle is distributed under the terms of the Creatve Commons Atributon 4.0 Internatonal License which permits unrestricted use, sharing, distributon, and reproducton in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creatve Commons license, and indicate if changes were made. Ismaeil & Saleh J Pure Appl Microbiol, 13(4), 2397-2404 | December 2019 Artcle 5824 | htps://doi.org/10.22207/JPAM.13.4.56 Print ISSN: 0973-7510; E-ISSN: 2581-690X RESEARCH ARTICLE OPEN ACCESS www.microbiologyjournal.org 2397 Journal of Pure and Applied Microbiology Sumac (Rhus coriaria L) as Quorum Sensing Inhibitors in Staphylococcus aureus Abdulilah Saleh Ismaeil*and Fraidoon A. Saleh Biology Department, Science College, Salahaddin University, Erbil, Kurdistan, Iraq. Abstract Diferent solvents were used for sumac extractons to fnd diferent actve compounds in each fracton, and these fractons were tested on Staphylococcus aureus (which isolated from sof white cheese), the (MIC) minimum inhibitory concentraton of each fracton were measured then sub-inhibitory concentraton (SIC) was used. We found that all fractons can inhibit quorum sensing in Staphylococcus aureus in a diferent rato. By using Real-tme PCR found that the diferent sumac fractons can inhibit the expression of tested genes (Sea, Seb, AgrA, RNAIII, and Hla). Furthermore, most sumac extracted fractons have the ability to decreasing bioflm and growth curve in Staphylococcus aureus signifcantly, while other fractons decreased them non-signifcantly. Keywords: Staphylococcus aureus, sumac extract, quorum sensing inhibitor, Bioflm, Growth curve.