Characterization of the neutralizing antibody response in a case of genetically linked HIV 1 superinfection 2 Deogratius Ssemwanga 1 *, Nicole A. Doria-Rose 2 *, Andrew D. Redd 3,4 * # , Andrea R. Shiakolas 2 , Andrew 3 F. Longosz 3 , Rebecca N. Nsubuga 1 , Billy N. Mayanja 1 , Gershim Asiki 1 , Janet Seeley 1,5 , Anatoli Kamali 1 , 4 Amy Ransier 2 , Samuel Darko 2 , Michael P. Walker 6 , Daniel Bruno 6 , Craig Martens 6 , Daniel Douek 2 , 5 Stephen F. Porcella 6 , Thomas C. Quinn 3,4 , John R. Mascola 2 , and Pontiano Kaleebu 1,5 6 1- Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) Uganda Research Unit on 7 AIDS, Entebbe, Uganda 8 2- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, 9 Maryland, USA 10 3-Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA 11 4-Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA 12 5-London School of Hygiene and Tropical Medicine, Department of Clinical Research 13 6- Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural 14 Research, NIAID, NIH, Hamilton MT, USA 15 # Correspondence: Dr. Andrew D. Redd 16 855 N. Wolfe St, Rangos Building, Room 527 17 Johns Hopkins Medical Institute 18 Baltimore MD, 21205 19 *-DS, NADR, and ADR contributed equally to the study. Abstract: 99 (100 max) Manuscript: 2000 20 (2000 max) 21 Short Title: Anti-HIV neutralizing antibody response in a linked HIV superinfection 22