Research Article Avocado Oil Supplementation Modifies Cardiovascular Risk Profile Markers in a Rat Model of Sucrose-Induced Metabolic Changes Octavio Carvajal-Zarrabal, 1 Cirilo Nolasco-Hipolito, 2 M. Guadalupe Aguilar-Uscanga, 3 Guadalupe Melo-Santiesteban, 4 Patricia M. Hayward-Jones, 1 and Dulce M. Barradas-Dermitz 5 1 Biochemical and Nutrition Chemistry Area, University of Veracruz, SS Juan Pablo II s/n, 94294 Boca del R´ ıo, Ver., Mexico 2 Department of Molecular Biology, Faculty of Resource Science and Technology, University Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia 3 Food Research and Development Unit, Veracruz Institute of Technology, Calz. M.A. de Quevedo 2779, 91860 Veracruz, Ver., Mexico 4 Pathology Laboratory, Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s/n, 94294 Boca del R´ ıo, Ver., Mexico 5 Biological-Chemistry Area, Veracruz Institute of Technology, Calz. M.A. de Quevedo 2779, 91860 Veracruz, Ver., Mexico Correspondence should be addressed to Octavio Carvajal-Zarrabal; ocarvajal@uv.mx Received 27 June 2013; Revised 16 December 2013; Accepted 17 December 2013; Published 25 February 2014 Academic Editor: Fabrizia Bamonti Copyright © 2014 Octavio Carvajal-Zarrabal et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Te purpose of this study was to evaluate the efects of avocado oil administration on biochemical markers of cardiovascular risk profle in rats with metabolic changes induced by sucrose ingestion. Twenty-fve rats were divided into fve groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.). Glucose, total cholesterol, triglycerides, phospholipids, low- and high-density lipoproteins (LDL, HDL), very low-density lipoprotein (VLDL), lactic dehydrogenase, creatine kinase, and high sensitivity C-reactive protein concentration were analyzed. Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case signifcantly so, without afecting HDL levels. An efect was exhibited by avocado oil similar to olive oil, with no signifcant diference between avocado oil extracted either by centrifugation or solvent in myocardial injury biochemical indicators. Avocado oil decreased hs-CRP levels, indicating that infammatory processes were partially reversed. Tese fndings suggested that avocado oil supplementation has a positive health outcome because it reduces infammatory events and produces positive changes in the biochemical indicators studied, related to the development of metabolic syndrome. 1. Introduction Food is a factor that plays a key role in life style, a determining infuence on health and quality of life. It is known that popula- tions with a high consumption of meat, dairy foods, and sugar have a higher mortality rate than those that feed mainly on fruits, vegetables, fsh, and unsaturated oils [1]. Undesirable efects on health are associated with an excessive intake of carbohydrates (sugars) and fats. Manifestations of health disorders in people with metabolic implications are related to the incidence and prevalence of chronic and degenerative diseases such as obesity, diabetes, cardiovascular disease, and dyslipidemia (low HDL-cholesterol and high triglycerides), among others [2, 3]. Although there are many factors that contribute to its development, one of the main causes that lead to these conditions is the diet that is consumed. A diet containing a great amount of nutrients produces a strong impact on structure, physiology, and cellular metabolism. In recent years, the increase in these diseases has become a global public health problem inspite of the increasing medical knowledge for their prevention and treatment; consequently, the nutritional aspect seems to remain vital. Hindawi Publishing Corporation Disease Markers Volume 2014, Article ID 386425, 8 pages http://dx.doi.org/10.1155/2014/386425