International Journal of Organic Chemistry, 2017, 7, 254-262 http://www.scirp.org/journal/ijoc ISSN Online: 2161-4695 ISSN Print: 2161-4687 DOI: 10.4236/ijoc.2017.73019 Aug. 11, 2017 254 International Journal of Organic Chemistry Cu-Pd Dual Catalyst System for Amide Styrylation Reaction from Potassium Styryltrifluoroborates and Amides Mohammad Al-Masum * , Mohammed Shahidul Islam, Wejdan Shaban Department of Chemistry, Tennessee State University, Nashville, TN, USA Abstract An interesting reaction procedure for the cross-coupling of potassium styryl- trifluoroborates and amides has been developed by using PdCl 2 (d t bpf)-CuI dual catalyst system. By applying this method, good numbers of amide styry- lation products are formed in 85% - 92% yields. Keywords Amide Styrylation Reaction, Dual Catalyst, Microwave 1. Introduction Nitrogen containing compounds are important because of their presence in nat- ural products, their presence in synthetic organic products, and they display wide-range of functionalities. The formation of the C-N bond is important as it opens avenues for introducing nitrogen in organic molecules. Buchwald and Hartwig have separately developed successful metal complexes and ligands for the construction of C-N bonds using transition metal-catalyst [1]-[7]. Although significant progress has occurred in this field, the formation of C-N bond through amide styrylation reaction has not been animated by many chemists. The pioneering work by Buchwald’s group on palladium-catalyzed intermolecu- lar amidation of aryl halides and effective use of Xantphos as ligand is promising [8]. In another development, Buchwald showed the copper-catalyzed amidation of vinyl halides and the effective use of N,N’-dimethyl ethylene diamine ligand [9]. Hartwig also reported the ligand effect of P( t Bu) 3 and Pd-catalyzed intermo- lecular cross-coupling of aryl bromides and chlorides with tert-butyl carbamate [10]. Other groups also reported palladium-catalyzed amide arylation reactions How to cite this paper: Al-Masum, M., Islam, M.S. and Shaban, W. (2017) Cu-Pd Dual Catalyst System for Amide Styrylation Reaction from Potassium Styryltrifluorobo- rates and Amides. International Journal of Organic Chemistry, 7, 254-262. https://doi.org/10.4236/ijoc.2017.73019 Received: June 30, 2017 Accepted: August 8, 2017 Published: August 11, 2017 Copyright © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access