Mossa M Morbat 1 , Azzawi M Hadi 2 * and Dekhel H Hadri 3 1 Department of Physiology, Tikrit Medical Collage, Iraq 2 Department of Surgery, Tikrit Medical Collage, Iraq 3 Department of Veterinary Medicine, Tikrit University, Iraq *Corresponding author: Azzawi M Hadi, Department of surgery, Tikrit Medical Collage, Iraq Submission: December 10, 2017; Published: March 23, 2018 Effect of Selenium in Treatment of Male Infertility Introduction The infertility rates vary between countries and from region to regions [1]. It is documented that around 15% of married couples are infertile and that approximately 50% of infertility is due to male factor [2]. Male infertility is defined as the failure to conceive after 12 months of regular unprotected intercourse [3,4]. Spermatozoa like all cells living in aerobic conditions, constantly face the oxygen (O2) paradox: O2 is required to support life, but its metabolites such as Reactive Oxygen Species ROS can modify cell functions, endanger cell survival or both [5]. Hence, ROS must be continuously inactivated to keep only a small amount necessary to maintain normal cell functions [6]. Malondialdehyde MDA is reactive species occurs naturally and is a marker for oxidative stress [7]. Glutathione itself also plays an important role in the protection of cells against oxidative and electrophilic stress caused by ROS and radiation [8,9]. Zinc salts have been shown to protect against oxidative damage and glutathione depletion in mice. Testosterone synthesis is zinc dependent in human. The sperms take up zinc from fluid after ejaculation, therefore, zinc content of sperm cell will increase after the exposure to seminal fluid, and it affected the maturation of spermatozoa [10]. Zinc deficient diet affect oxidative stress due to decrease in glutathione & increase in MDA in both semen & serum [11,12]. (Se) is an essential dietary micronutrient required for maintenance of male fertility. [13] About 20-40% of male infertility is considered to be due to deficient sperm production to which selenium deficiency has been linked [14]. The biological functions associated with selenium besides male fertility include prevention of cancer, cardiovascular disease, viral mutation, endocrine and immune function as well as modulating inflammatory response [15]. Limited data is available on the effects of selenium on male reproduction. Hurst et al .reported that fertile males had significantly higher selenium levels in their seminal fluid than infertile men. This study shows the importance of selenium in male reproduction and the probable relationship between male infertility and selenium [16]. Materials and Methods A longitudinal study in which samples were obtained from urology clinic in Tikrit teaching hospital, private clinic, from 1-11- 2009 to 1-9-2010. A questionnaire was prepared to obtain the information from the infertile men before semen analysis which include name, age, job, smoking, marriage duration, surgical Research Article 1/4 Copyright © All rights are reserved by Azzawi M Hadi. Volume 1 - Issue - 5 Abstract Infertility is a problem of global proportions. The World Health Organization (WHO) estimates that 8-12% of couples around the world experience difficulty conceiving a child. Spermatozoa like all cells living in aerobic conditions constantly face the oxygen (O2) paradox. Evidence now suggests that Reactive Oxygen Species (ROS)-mediated damage to sperm is a significant contributing pathology in 30–80% of cases. Materials and methods: A longitudinal study involves 12 infertile men were treated with Selenium capsule 50microgram (one cap.) once daily at night. The treatments continued for 3months. History and clinical examination with semen analysis, as well as serum and seminal plasma study for zinc, magnesium, Malondialdehyde (MDA), and glutathione. FSH, LH, and Testosterone also done. All these studies done both before and after treatment. Statistical analysis done. Results and discussion: There is significantly increase in sperm count, motility, viability, normal Sperm morphology, and ejaculate volume of infertile men compared after treatment with selenium. Serum Mg, Serum FSH, Serum LH, and Serum testosterone, and serum glutathione levels were significantly increased. Serum MDA significantly decreased in infertile men after treatment with selenium comparing with before treatment. These results supported by many studies published that explained and conclude the effect of selenium on semen quality. Conclusion: Selenium can be used as a single agent in treatment of male infertility. Keywords: Selenium; Male infertility; Semen analysis Experimental Techniques in Urology & Nephrology C CRIMSON PUBLISHERS Wings to the Research ISSN 2578-0395