Article Identification, Treatment, Initial and Long-Term Re- sults of Chronic Muscle Spasm Induced Chronic Pain Treated with the CMECD  Procedure Roger H. Coletti 1, * 1 Interventional Health, PA, USA. Address: Lewes, DE, USA. Suite 125, 16529 Coastal Highway, Lewes, DE 19958-3697. Tel: 1-302-645-1500. ORCID iD: 0000-0003-2569-4435 * Correspondence: rogercoletti@gmail.com Abstract: This article was not intended to be a complete report of a standard clin- ical trial. It is a report of the outcomes of preliminary data for validation of the CMECD procedure (Coletti Method of EMG ChemoDenervation) protocol for the treatment of chronic pain resulting from chronic muscle spasm. Methods are here detailed on how to approach the patient with chronic pain, identify the presence of chronic muscle spasm, undertake the treatment protocol and how to perform the follow up process to confirm that chronic pain secondary to chronic muscle spasm was the accurate diagnosis. Furthermore, this article presents the results of a cohort of more than 90 patients treated by the CMECD procedure regarding location and duration of prior pain, prior treatment strategies, degree of success in resolving pain and duration of relief. Outcome data consisting of patient and staff reporting of specific situations in which the chronic pain treatment was suc- cessful has been included to help establish the “believability” of outcome suc- cesses and to elucidate the potential life altering effects of successful treatment of chronic pain secondary to chronic muscle spasm. This article will hopefully in- crease the interest in this treatment protocol and increase the chance that a classi- cal international clinical trial will be undertaken. Keywords: EMG; muscle; spontaneous electrical activity (SEA); spasm; pain; CMECD protocol, phenoxybenzamine-lidocaine mixture 1. Introduction This article is not a complete report of a standard clinical trial. It is a report of the outcomes of preliminary data for validation of the CMECD  procedure (Coletti Method of EMG ChemoDenerva- tion) for the treatment of chronic pain resulting from chronic muscle spasm that was compiled over a 15-year period. [1,2,3,4] Methods are here detailed on how to approach the patient with chronic pain, identify the presence of chronic muscle spasm, undertake the treatment protocol and how to perform the follow up process to confirm that chronic pain secondary to chronic muscle spasm was the accurate diagnosis. Furthermore, the survey results of a cohort of more than 90 patients treated by the CMECD  procedure regarding duration of prior pain, location of pain, prior treatment strategies, degree of suc- cess in resolving pain and duration of relief are presented. Outcome data consisting of patient and staff reporting of specific situations in which the chronic pain treatment was successful has been included to help establish the “believability” of outcome successes and to elucidate the potential life altering effects of successful treatment of chronic pain secondary to chronic muscle spasm. This article is intended to demonstrate that chronic pain when resulting from chronic muscle spasm can be treated successfully with long-term results with the use of the CMECD procedure. It will hopefully increase the interest in Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 17 February 2022 doi:10.20944/preprints202202.0104.v2 © 2022 by the author(s). Distributed under a Creative Commons CC BY license.