www.iajpr.com Page1645 Indo American Journal of Pharmaceutical Research, 2018 ISSN NO: 2231-6876 FORMULATION, OPTIMIZATION AND EVALUATION OF RASAGILINE MESYLATE IN SITU NASAL GEL Mamatha Kola * , G. Kaushal Puri, M. Tanveer Unnisa, J. Swapna, K. Phanivarma S.S.J College of Pharmacy, V.N.Pally, Gandipet, Hyderabad, 500075. Corresponding author Mamatha. Kola S.S.J College of Pharmacy, V.N. pally, Gandipet, Hyderabad, 500075. Copy right © 2018 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 28/06/2018 Available online 30/09/2018 Keywords Mucoadhesive, Nasal Gel, Novel Dosage Form, Rasagiline Mesylate, Carbopol 934, HPMC, Sodium Alginate. The aim of the present study is to formulate and evaluate nasal insitu gel of Rasagiline Mesylate. Nasal gels were prepared using combination of polymers like carbopol 934, HPMC K4M and sodium alginate and evaluated in terms of clarity, viscosity, gelation, ex vivo drug permeation studies. Ex vivo drug permeation profiles showed that formulation containing sodium alginate provided a better controlled release of the drug than the other formulations. Formulation F 3 showed better drug release of about 87.62% and it exhibited better in situ gelling properties, p H , clarity and viscosity. Mucoadhesive insitu nasal gel of Rasagiline mesylate delivers the drug directly to brain and provides controlled release of the drug. Please cite this article in press as Mamatha. Kola et al. Formulation, Optimization and Evaluation of Rasagiline Mesylate in Situ Nasal Gel. Indo American Journal of Pharmaceutical Research.2018:8(09).