Annals of Advanced Biomedical Sciences ISSN: 2641-9459 Dose-Dependent Effect of Short-Term Repeated Exposure to Amitraz on Some Reproductive Parameters in Male Albino Rats Ann Adv Biomed Sci Dose-Dependent Effect of Short-Term Repeated Exposure to Amitraz on Some Reproductive Parameters in Male Albino Rats Seriki SA 1 *, Adebayo OF 2 and Mbakwe PN 2 1 Department of Physiology, College of Medicine, Edo University, Nigeria 2 Department of Physiology, College of Medicine, Bingham University, Nigeria *Corresponding author: Seriki Samuel Adinoyi, Department of Physiology, College of Medicine, Edo University, Iyamho, Nigeria, Email: seriki.adinoyi@gmail.com Abstract Amitraz is a pesticide used in agriculture and public health to control insects, weeds, animals, and vectors of disease. Although the use of pesticides is of benefit in general, abuse of the pesticides is harmful due to their potential toxicity to humans and animals. Present study examined the effect of the pesticide on the male reproductive parameters of the male albino rats. 20 rats were grouped into four. Group 1 was control, Group 2 was given low dose Amitraz, Group 3 was median dose, and Group 4 was high dose. The administration was for a period of 21 days. Results showed that Amitraz has dose dependent toxicity effect on the reproductive parameter of the rat. Amitraz is toxic to the reproductive parameters of the albino rat, and could lower sperm concentration, sperm motility, and sperm morphology. By implication, Amitraz is toxic to the reproductive system and could cause infertility in male. Keywords: Infertility; Sperm Concentration; Toxicity; Pesticide; Repeated Exposure Introduction A pesticide is any substance or mixture of substances intended for preventing, destroying or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals causing harm during or otherwise interfering with the production processing, storage, transport or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or substances which may be administered to animals for the control of insects, arachnids or other pests in or on their bodies [1]. They are widely used for preservation across the world. Over the past years, estrogenic activities of pesticides have been the focus of research. However, not much attention has been paid to anti-androgenic effects of the pesticides for the observed degeneration in male reproductive health. This is the aim of this study; to determine their effects on male reproductive system. Research Article Volume 2 Issue 1 Received Date: May 05, 2019 Published Date: May 24, 2019 DOI: 10.23880/aabsc-16000125