Available online at www.sciencedirect.com journal homepage: www.elsevier.com/locate/burns The investigation of the effects of occupation- based intervention on anxiety, depression, and sleep quality of subjects with hand and upper extremity burns: A randomized clinical trial Mahnoosh Khanipour a , Laleh Lajevardi b, ⁎ , Ghorban Taghizadeh b , Akram Azad b , Hooman Ghorbani c a School of Rehabilitation Sciences, Iran University of Medical Sciences (IUMS), Tehran, Iran b Rehabilitation Research Center, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences (IUMS), Tehran, Iran c Department of Occupational Therapy, Shahid Motahhari Specialized Burns Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran article info Article history: Accepted 21 February 2022 Keywords: Burns Psychological factors Sleep disorder Occupational therapy Occupational performance abstract Aim: This study aimed to investigate the effects of occupation-based intervention on psychological factors and sleep quality of subjects with hand and upper extremity burns. Methods: In this randomized controlled intervention trial, a total of 20 patients were ran- domly assigned to one of the control group or intervention group. The control group only received traditional rehabilitation. However, the intervention group received traditional rehabilitation and Cognitive Orientation to daily Occupational Performance (CO-OP), re- spectively (during 18 sessions, 45 min/day in both groups). Occupational therapy sessions were held three times a week for a six-week duration. Occupational performance and sa- tisfaction, anxiety, depression, and sleep quality were measured before the intervention and in weeks 2, 6, and 14 (follow-up) using Canadian Occupational Performance Measure, Beck Anxiety Inventory, Self-rating Depression Scale, and Pittsburgh Sleep Quality Index, respectively. Findings: The results of the present study show that there were signifcant changes in all the studied variables in the two groups. However, these changes (P ≤ 0.05) were not sta- tistically signifcant between these two groups. Conclusion: The results of this study show that occupation-based interventions are as ef- fective as traditional therapeutic interventions on improving the anxiety, depression, and sleep quality in patients with hand burn injuries. © 2022 Elsevier Ltd and ISBI. All rights reserved. https://doi.org/10.1016/j.burns.2022.02.014 0305-4179/© 2022 Elsevier Ltd and ISBI. All rights reserved. ⁎ Corresponding author. E-mail address: lajevardi.l@iums.ac.ir (L. Lajevardi). burns xxx (xxxx) xxx–xxx Please cite this article as: M. Khanipour, L. Lajevardi, G. Taghizadeh et al., The investigation of the effects of occupation- based intervention on anxiety, depression, and sleep quality of subjects with hand and upper extremity burns: A randomized clinical trial, Burns, https://doi.org/10.1016/j.burns.2022.02.014i