ARTIKEL HASIL PENELITIAN Acta Pharmaceutica Indonesia  2017 Vol. 42  No. 2 hlm. 69-75 IDENTIFICATION OF DRUG-RELATED PROBLEMS ON BETA LACTAM ANTIBIOTICS USED FOR PEDIATRIC AT A SECONDARY- CARE HOSPITAL IN CIMAHI, INDONESIA Zulfan Zazuli 1 *, Tomi Hendrayana 1 , Siti Farah Rahmawati 1 , Shalvierra Polyta Fitriah 1 Information Author 1 Department of Pharmacology-Clinical Pharmacy School of Pharmacy Institut Teknologi Bandung Jl Ganesa 10 Bandung 40132 *Corresponding Author: Zulfan Zazuli E-mail: zulfan@fa.itb.ac.id ABSTRACT World Health Organization (WHO) estimated that >50% of medicines are used inappropriately. One that posess highest risk due to inappropriate use is beta-lactam antibiotic, espescially in pediatric patient since the organ function in pediatric patient has not completely developed as in adult yet. This cross-sectional study was performed to retrospectively identify drug-related problems (DRPs) occurred during beta-lactam therapy in pediatric hospitalized in a secondary- care hospital in Cimahi. Amedication-use criteria based on the current literatures was created as an assessment standard tools. Furthermore, identification of DRPs based on The Pharmaceutical Care Network Europe (PCNE) v6.2 classification was carried out to 351 patients hospitalized from January to March 2015. As many as 458 potential DRPs were found in those patients including 22 cases inappropriate drugs (category C1.1), 127 cases no indication for drug (C1.2), 42 cases inappropriate combination of drugs, or drugs and food (C1.3), 1 case of too many drugs prescibed for indication (C1.6), 137 cases drug dose too low (C3.1), 89 cases drug dose too high (C3.2), 39 cases duration of treatment too short (C4.1) and 1 case of duration of treatment too long (C4.2). The potential DRPs was estimated to be occured for approximately 1-2 DRPs per patient. Keywords: drug-related problems; beta-lactam antibiotic; pediatric; pharmaceutical care IDENTIFIKASI PERMASALAHAN TERKAIT OBAT (DRUG-RELATED PROBLEMS) ANTIBIOTIK BETA LAKTAM PADA PASIEN ANAK SUATU RUMAH SAKIT DI KOTA CIMAHI, INDONESIA ABSTRAK World Health Organization (WHO) memperkirakan >50% obat di dunia digunakan tidak sesuai dengan rekomendasi. Salah satu obat yang memiliki resiko tinggi bila digunakan secara tidak rasional yaitu antibiotik beta laktam terutama apabila digunakan pada pasien pediatrik karena fungsi organ yang belum sempurna seperti orang dewasa. Studi potong lintang ini dilakukan untuk mengidentifikasi permasalahan terkait obat (drug-related problems/DRPs) antibiotik beta laktam secara retrospektif pada pasien anak rawat inap di suatu rumah sakit rujukan pelayanan sekunder di Cimahi. Selanjutnya dibuat kriteria penggunaan obat sebagai standar untuk menilai ketepatan penggunaan obat disusun berdasarkan pustaka mutakhir. Kemudian dilakukan identifikasi DRPs pada 351 pasien yang dirawat pada bulan Januari hingga Maret 2015 berdasarkan klasifikasi The Pharmaceutical Care Network Europe (PCNE) v6.2). Ditemukan 458 jenis potensi ketidaktepatan penggunaan antibiotik beta-laktam (DRP) terdiri dari 22 kasus obat tidak tepat (kode C1.1), 127 kasus obat tanpa indikasi (C1.2), 42 kasus ketidaktepatan kombinasi obat-obat / obat makanan (C1.3), 1 kasus terlalu banyak obat untuk 1 indikasi (C1.6), 137 kasus dosis terlalu rendah (C3.1), 89 kasus dosis terlalu tinggi (C3.2), 39 kasus durasi terapi kurang (C4.1), dan 1 kasus durasi terapi lebih (C4.2). Potensi terjadinya DRP diperkirakan sekitar 1-2 kasus DRP per pasien. Kata kunci: drug-related problems; masalah penggunaan obat; antibiotik beta laktam; pediatrik; asuhan kefarmasian