_____________________________________________________________________________________________________ *Corresponding author: E-mail: vemuripraveen@gmail.com; Journal of Pharmaceutical Research International 34(26A): 85-94, 2022; Article no.JPRI.83770 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Study on Molecular Basis of Cancer Induced Angiogenesis Adithi Sanikommu a , Sai Akshita Vaddi a , Vandana Yeddula a , Lakshmi Saatvika Manikyala a , Chaitanya Krishna Kommineni a , Lakshmi Prasanna Sanikommu a , Susmitha Rani Talla a and Praveen Kumar Vemuri a* a Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i26A35974 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/83770 Received 12 January 2022 Accepted 16 March 2022 Published 22 March 2022 ABSTRACT Cancer is a disease caused by defective cells that have an uncontrollable ability to proliferate without regard for the physiological organ. Cancer is a complicated multi-factorial, multi-staged, and multi-mechanistic disease. Within the initiation and course of manifestation, it comprises the interaction of environmental and host elements. Inherited genetic dispositions have a significant role in 5-10% of breast cancer cases and 5- 13% of colon cancer cases. Viral infections cause about 7% of cancer fatalities in developed countries; 4% are due to occupational hazards; 2% are due to sunlight; 2% are due to pollution of air, water, and soil; and less than 1% are due to food components and business products. Keywords: Etiology; epidemiology; cancer; angiogenesis; MMP; hypoxia. 1. INTRODUCTION When fed persistently, several chemical and physical cancer agents can cause one or more of a variety of mutations in cells [1]. A desired array of cancer-causing chemical substances is man- made, pesticides, pharmaceutical chemicals, or food additives [2]. Carcinogens are a broad Review Article