ORIENTAL JOURNAL OF CHEMISTRY
www.orientjchem.org
An International Open Access, Peer Reviewed Research Journal
ISSN: 0970-020 X
CODEN: OJCHEG
2021, Vol. 37, No.(3):
Pg. 553-567
This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC- BY).
Published by Oriental Scientifc Publishing Company © 2018
Reactions of MoCl
5
and MoO
2
Cl
2
with Succinimide,
1,4-Diaminobutane, 3-Methylpyridine, 1,3-Diaminopropane,
Pyrazole and 1-Methylpyrrolidine in Tetrahydrofuran
RAKESH KUMAR and GURSHARAN SINGH*
Research Scholar registered with Punjab Technical University, Kapurthala, India.
Department of Applied Chemistry, Giani Zail Singh Campus College of
Engineering & Technology, Dabwali Road, MRSPTU Bathinda-151001, India.
*Corresponding author E-mail: gursharans82@gmail.com
http://dx.doi.org/10.13005/ojc/370306
(Received: May 04, 2021; Accepted: June 05, 2021)
ABSTRACT
It has been reported that molybdenum may extract oxygen from oxygen containing
ligands. Oxo complexes of above bases with transition metals show numerous applications
and are biologically active. So to study the biological activity of molybdenum complexes and to
study oxo abstraction reactions by molybdenum, reactions of succinimide/1,4-diaminobutane/
3-methylpyridine/1, 3-diaminopropane/pyrazole/1-methylpyrrolidine with MoCl
5
/MoO
2
Cl
2
have been
carried out, in THF medium using equimolar/bimolar quantities of the ligand, at normal temperature.
The products thus obtained are: Mo
2
O
3
Cl
5
(C
4
H
5
NO
2
)
2
(C
4
H
8
O)
2
,[1]; Mo
2
O
2
Cl
2
(C
4
H
5
NO
2
)
2
(C
4
H
8
O)
2
,[2];
MoO
2
Cl
2
(HNCH
2
CH
2
CH
2
CH
2
NH
2
)
2
,[3]; Mo
3
Cl
8
(C
6
H
7
N)
4
(C
4
H
8
O)
2
, [4]; Mo
3
Cl
6
(C
6
H
7
N)
6
(C
4
H
8
O)
6
,[5];
MoO
2
Cl
3
(HNCH
2
CH
2
CH
2
NH
2
)
2
,[6]; Mo
2
O
4
Cl
4
(C
3
H
4
N
2
)
4
, [7] and Mo
2
O
6
Cl
8
(C
5
H
11
N)
4
, [8]. There is oxygen
abstraction by molybdenum during the reaction from the oxygen containing solvent THF. Formulations
of these compounds were made and their properties were studied with FTIR (transmission mode),
1
H NMR/
13
C NMR, microbiological studies, elemental analysis (Mo, Cl, C, H, N) and LC-MS. All
preparations, separations and isolations were executed in vacuum line and inert atmosphere (dry
nitrogen) to eliminate any oxidation/hydrolysis of products by air/moisture. The formulations proposed
have been supported by the above characterization studies.
Keywords: Succinimide, 1, 4-diaminobutane, 3-methylpyridine,
1, 3-diaminopropane, pyrazole, 1-methylpyrrolidine.
INTRODUCTION
Succinimide
Succinimides
1
are involved in various
biological applications. Succinimide is a constituent
of various biologically active compounds having
signifcance as: CNS depressant
2
, hypotensive
3
,
antitumour
4
, cytostatic
5
, bacteriostatic
6
, nerve
conduction blocking
7
, muscle relaxant
8
, anorectic
9
,
antibacterial
10
, analgesic
11
, anti-convulsant
12
, anti-
tubercular
13
, antispasmodic
14
and antifungal
15
.
Succinimide can form complex through
oxygen atom. Deprotonated succinimide (on removal
of hydrogen from nitrogen) can form complex through
the nitrogen atom. In deprotonated succinimide, the