_____________________________________________________________________________________________________ *Corresponding author: E-mail: bitatipu@gmail.com; Annual Research & Review in Biology 37(2): 87-101, 2022; Article no.ARRB.68317 ISSN: 2347-565X, NLM ID: 101632869 Lycopene - A Review: Chemistry, Source, Health Role, Extraction, Applications Md. Asaduzzaman a* a State University of Bangladesh, Bangladesh. Author’s contribution The sole author designed, analyzed, interpreted and prepared the manuscript. Article Information DOI: 10.9734/ARRB/2022/v37i230490 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/68317 Received 07 March 2021 Accepted 12 May 2021 Published 24 March 2022 ABSTRACT Lycopene is an unsaturated carotenoid pigment which is acyclic and open chain, of great dietary prominence obtained mainly from colored plant sources. It is a phytochemical which is found mainly in red amaranth, tomatoes, water melon and other plants and fruits mostly red colored which covered various antioxidant which attracted attentions due to its biological properties. Lycopene has critical role in the prevention of tumor and cancer. Various ways can be utilized to identify, extract and purify lycopene from various sources by efficient analytical support. Several analyses have been attended for the extraction and quantification of lycopene in various natural sources such as various red leaf plants and fruits. This review study highlights lycopene as a carotenoid pigment including auspicious nutraceutical implications, and counts the important plant and also microbial sources for its production, and methods to calculate its bioavailability and utilization. Keywords: Lycopene; chemistry; extraction; applications. 1. INTRODUCTION Lycopene (C 40 H 56 ) is an open chain, acyclic, fat- soluble, unsaturated, natural carotenoid pigment and mainly utilized in the coloring of different types and kinds of foodstuffs [1]. 11-conjugated linearly arranged double bonds in lycopene structure make a unique characteristic which is easy to absorption in the human body and sort it bioavailable [2]. Review Article