_____________________________________________________________________________________________________ *Corresponding author: E-mail: mahfuzarahman49@gmail.com; Journal of Advances in Medical and Pharmaceutical Sciences 23(11): 29-38, 2021; Article no.JAMPS.81284 ISSN: 2394-1111 Comparative Analysis of In vitro Quality Parameters of Different Brands of Marketed Ciprofloxacin Tablets Available in Bangladesh Mst. Mahfuza Rahman a *, Khurshida Akter a , Masudur Rahman a , Jinat Fatema Shorna a , Amitav Lahiry b and Mir Imam Ibne Wahed b a Department of Pharmacy, Comilla University, Comilla-3506, Bangladesh. b Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMPS/2021/v23i1130269 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/81284 Received 23 October 2021 Accepted 25 December 2021 Published 26 December 2021 ABSTRACT Aim: Ciprofloxacin is a broad-spectrum antibiotic under the group of drugs called fluoroquinolones. It is extensively being manufactured and marketed drug by many national and multinational pharmaceutical companies. The purpose of this study was to compare the quality of different brands of ciprofloxacin 500mg tablets available in Bangladesh using quality characteristics such as weight variation, hardness, thickness, friability, disintegration time, and dissolution profile. Methodology: The tablets' overall quality criteria, such as weight variation, hardness, thickness, diameter, friability, disintegration time, and dissolving profile, were evaluated using established protocols. An electric analytical balance was employed to measure weight variation. An automated hardness tester was used to determine the hardness, thickness, and diameter. A friabilator was used to determine the degree of friability. A disintegration equipment and a dissolution tester were used to examine the disintegration time and dissolution profile, respectively. Results: In this study, all the values were compared with the standards. All brands had been passed for the weight variation test, because no tablets surpass the ± 5 % weight variation. The weight variation range was from 714.57±4.08 mg (brand C) to 837.92±7.49 mg (brand E). In hardness testing procedure, all brands of ciprofloxacin 500mg tablets were within the specified limit. The average hardness of the items ranges from 11.11±1.44 kgF to 19.26±2.20 kgF respectively. Original Research Article