62 ISSN 0022-9040. Кардиология. 2020;60(10). DOI: 10.18087/cardio.2020.10.n1117 ОРИГИНАЛЬНЫЕ СТАТЬИ § Ahmet Çağrı Aykan 1 , Duygun Altintas Aykan 2 , Mahmut Tuna Katırcıbaşı 1 , Sami Özgül 1 1 Department of Cardiology, Kahramanmaras Sutcu Imam University, Faculty of Medicine Kahramanmaras, Turkey 2 Department of Pharmacology, Kahramanmaras Sutcu Imam University, Faculty of Medicine Kahramanmaras, Turkey Management of radio-contrast allergy in radio-contrast allergic patients undergoing coronary angiography and intervention Objectives Radiocontrast agents (RCA) allergy occurs in 0.04 % – 0.22 % of patients. However, the risk of allergic reaction increases as 16 % to 35 % in patients with prior RCA allergy. Herein we reported our experience in patients with a prior history of RCA induced anaphylaxis who underwent coronary angiography (CAG) and intervention. Methods This retrospective study included 11 patients with prior history of RCA anaphylaxis who underwent CAG and / or intervention at our clinic between May 2016 and September 2019. The mean age of the patients was 61.8±8.99 years, 8 (72.7 %) were female, 9 (81.8 %) had hypertension, 6 (54.5 %) – diabetes mellitus, 11 (100 %) – dyslipidemia, 8 (72.7 %) patients were current smokers, 4 had prior history RCA allergy after i.v. RCA administration in contrast enhanced computed tomography and 7 patients experienced RCA allergy after CAG. All patients had prior severe anaphylaxis reaction. All patients were pretreated with intravenous feniramin maleat 45.5 mg and methylprednizolone 80 mg one hour before the procedure and dexametazon 8 mg after the procedure. Results CAG and intervention was successfully completed in all patients. Two patients had breakthrough RCA induced anaphylaxis, theyhad urticarial, itching, dyspnea and chest tightness, angioedema during coronary artery stenting. Additional dose of i.v. methylpredinisolene 80 mg, salbutamol nebulae and i.v. adrenalin 1 mg administration rapidly stabilize the patients. All patients were successfully treated and uneventfully discharged after percutaneous coronary intervention. Conclusion Management of patients with prior RCA adverse drug reaction may be complex. However when CAG and / or intervention is required in such patients it may be safely performed with premedication. Keywords Radiocontrast; allergy; coronary angiography; premedication protocols For citation Ahmet Çağrı Aykan, Duygun Altintas Aykan, Mahmut Tuna Katırcıbaşı, Sami Özgül. Management of radio-contrast allergy in radio-contrast allergic patients undergoing coronary angiography and intervention. Kardiologiia. 2020;60(10):62–65. [Russian: Ахмет Чагры Айкан, Дуйгун Алтинтас Айкан, Махмут Тунец Катырджибаши, Сами Озгюль. Лечение радиоконтрастной аллергии у пациентов, перенесших коронарную ангиографию и вмешательство. Кардиология. 2020;60(10):62–65] Corresponding author Ahmet Çağrı Aykan. E-mail: ahmetaykan@yahoo.com Introduction Adverse drug reactions are unexpected, noxious, unintended and dose-independent reactions occurring afer the administration of drugs [1]. Systemic allergic reactions are classifed as IgE-mediated anaphylaxis and systemic non-IgE-mediated anaphylaxis (anaphylactoid reactions) [2, 3]. Radiocontrast agents (RCA) allergy is a severe life- threatening condition requiring prompt intervention. It was reported that severe RCA allergy occurs in 0.04 % – 0.22 % of patients [3–9]. However the risk of allergic reaction increases as 16 % to 35 % in patients with prior RCA allergy [5–9]. There is no completely protective pretreatment regimen from RCA anaphylaxis. However some pretreatment regimens including prednisone, diphenhydramine, and occasionally cimetidine and ephedrine are commonly used [1, 8]. These regimens reduce the risk of repeat reactions to 3.1 % – 9 % [5, 6]. Allergic reactions occur 2.1 % to 18 % of patients despite pretreatment with these regimes [9–12]. Coronary artery disease is still the leading cause of death. Coronary angiography (CAG) and intervention is the integral part of management of coronary artery disease. Current guidelines suggested the use of steroids and antihistamines in patients with a prior history of RCA anaphylaxis prior to cardiac catheterization. However the data regarding the management of such patients is scarce. Herein we reported our experience in patients with a prior history of RCA adverse drug reactions who underwent CAG and intervention. Methods and study design Tis retrospective study included 11 patients with prior history of RCA anaphylaxis who underwent CAG and/or