J Sci Comput (2012) 52:340–359 DOI 10.1007/s10915-011-9547-6 A Variational Data Assimilation Procedure for the Incompressible Navier-Stokes Equations in Hemodynamics Marta D’Elia · Mauro Perego · Alessandro Veneziani Received: 28 April 2011 / Accepted: 12 October 2011 / Published online: 6 November 2011 © Springer Science+Business Media, LLC 2011 Abstract We propose a data assimilation (DA) technique for including noisy measurements of the velocity field into the simulation of the Navier-Stokes equations (NSE) driven by hemodynamics applications. The technique is formulated as an inverse problem where we use a Discretize-then-Optimize approach to minimize the misfit between the recovered ve- locity field and the data, subject to the incompressible NSE. The DA procedure for this nonlinear problem is a combination of two approaches: the Newton method for the NSE and the DA procedure we designed and tested for the linearized problem. We discuss conditions on the location of velocity measurements that guarantee the well-posedness of the minimiza- tion process for the linearized problem. Numerical results, with both noise-free and noisy data, certify the theoretical analysis. Moreover, we consider 2D non-trivial geometries and 3D axisymmetric geometries. Also, we study the impact of noise on non-primitive variables of medical interest. Keywords Computational fluid dynamics · Optimization · Inverse problems · Data assimilation · Hemodynamics 1 Introduction Numerical methods for incompressible fluid dynamics have recently received strong im- pulse from applications to the cardiovascular system (see e.g. [8, 9, 28]). A strong integra- tion of data and numerical modeling is expected to bring a great benefit to the development of mathematical and computational tools with a clinical impact. The introduction and im- provement of measurement and imaging devices enhance the integration process and opens new challenges; as an example Fig. 1 reports an MRI [6] of the ascending aorta where blood M. D’Elia () · A. Veneziani Dept. of Mathematics and Computer Science, Emory University, 400 Dowman Drive, Atlanta, GA 30322, USA e-mail: mdelia2@mathcs.emory.edu M. Perego Dept. of Scientific Computing, Florida State University, Tallahassee, FL, USA