www.wjpps.com Vol 3, Issue 2, 2014. 1578 Shaundarya Kumar et al. World Journal of Pharmacy and Pharmaceutical Sciences BIOAVAILBILITY ENHANCEMENT OF ARTESUNATE USING SOLID DISPERSION TECHNIQUES Shaundarya Kumar * 1 , Dr.Dinesh Chandra 2 , Rakesh Singh 3 , Vijay Kumar Singh 4 , Usha Rai 5 , Vaibhav Prakash Srivastava 6 * 1 Kamala Nehru Institute of Management & Technology ,Sultanpur ,U.P. 2,3,5 Assit. Professor Kamala Nehru Institute of Management & Technology ,Sultanpur ,U.P. 4 Vishveshwarya Institute of Medical Sciences, G. B. Nagar,U.P. ABSTRACT In the present work, an attempt has been made to enhance solubility and dissolution of poorly water soluble drug, Artesunate by preparing solid dispersions using two hydrophilic polymers namely ,β- cyclodextrin and PEG 6000.Drug carrier solid dispersions were prepared by solvent Physical mixing method. Solid dispersions of Artesunate with β-cyclodextrin and PEG 6000 markedly increase the solubility and dissolution of solid dispersion compared to the free form of Artesunate. The results were compared with marketed tablet of Artesunate. The drug carrier interactions in the solid state were investigated using saturated solubility studies, FTIR spectroscopy, X- ray diffraction and differential scanning calorimeter. The developed formulation overcome and alleviates the drawbacks and limitations of Artesunate sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Artesunate. Keywords: Artesunate, Solid dispersion. Bioavailability enhancement, β-cyclodextrin. INTRODUCTION Bioavailability refers to the rate and extent of the drug absorbed in the systemic circulation after administration. Oral delivery, the most convenient mode of drug administration has certain limitations, the most important being the low bioavailability of certain drugs. Drugs having low bioavailability require to be administered at a higher dose as only a small fraction of the administered dose is absorbed in the systemic circulation and reach the target site. 1 WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Volume 3, Issue 2, 1578-1595. Research Article ISSN 2278 – 4357 Article Received on 17 November 2013, Revised on 20 December 2013, Accepted on 08 January 2014 *Correspondence for Author: Dr. Saundarya kumar Kamala Nehru Institute of Management & Technology, Sultanpur ,U.P., India.