Research Article Point-of-Care(POC)UrinaryL-TypeFattyAcid-BindingProtein (u-LFABP)UseinCriticallyIll,VeryPretermNeonates HennyAdrianiPuspitasari , 1 EkaLaksmiHidayati , 1 RetnoPalupi-Baroto , 2 DiashatiRamadhaniMardiasmo , 3 andRosalinaDewiRoeslani 4 1 Division of Nephrology, Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 2 Division of Nephrology, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia 3 Medical Technology Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 4 Division of Perinatology, Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia Correspondence should be addressed to Eka Laksmi Hidayati; eka.laksmi@ui.ac.id Received 29 October 2021; Revised 31 December 2021; Accepted 19 February 2022; Published 19 March 2022 Academic Editor: David B. Kershaw Copyright © 2022 Henny Adriani Puspitasari et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preterm neonates are born with fewer functional nephrons, rendering them vulnerable to secondary insult. ese insults are associated with acute kidney injury (AKI); thus, structural damage must be detected as early as possible. Urinary L-type fatty acid- binding protein (u-LFABP) has been proposed as a highly suitable kidney injury biomarker during prematurity. We aimed to analyze the use of POC u-LFABP in critically ill, very preterm neonates. is study was conducted at the neonatal intensive care unit (NICU), Dr. Cipto Mangunkusumo General Hospital, from November to December 2020. Baseline characteristics were recorded from electronic medical records. u-LFABP examination utilized stored urine samples from a previous study and was performed using a LFABP POC test kit. e proportion of abnormal u-LFABP (83.3%) was highest at 72 hours. Neonates with older gestational age (0–48 hours; p � 0.017) and higher birth weight (0–48 hours; p � 0.022, 72 hours; p � 0.013) had normal u-LFABP levels. Neonates exposed to nephrotoxic agents showed higher proportion of abnormal u-LFABP (0–48 hours; p � 0.006). Longer invasive mechanical ventilation (IMV) period was observed in neonates with abnormal u-LFABP levels at 0–48 hours (7.44 ± 7.9 vs. 1.50 ± 2.9 days; p � 0.011). We found an association between complication rates and poorer disease outcome trends with abnormal u-LFABP; however, this relationship was not supported statistically. In conclusion, this study demonstrated that u-LFABP can be detected using bedside POC kit in critically ill very preterm neonates and those exposed to nephrotoxic agents may be at risk for kidney injury, confirmed by abnormal u-LFABP levels. 1.Introduction e WHO defines preterm birth as all births before 37 weeks of gestation, with subcategories including very (<32 weeks’ gestation) and extreme (<28 weeks’ gestation) preterm births [1]. In 2014, Indonesia was stated as the fifth leading country regarding high numbers of preterm births, esti- mated at 10.4% of all live births [2]. In 2018, our hospital, a tertiary national referral facility, observed 507 preterm live births, of which 112 were very preterm. e survival rate was reportedly 58.9% [3]. One of the preterm birth complica- tions that is a leading cause of death is acute kidney injury (AKI), which is estimated to occur in 30% of preterm ne- onates and around 18% in neonates born at 29 weeks to less than 36 weeks of gestational age [4]. Intrauterine nephrogenesis begins at 8 weeks of gestation and continues up to approximately 34–36 weeks of gestation, with over 60% of nephrons forming within the last preg- nancy trimester [5]. Nephrogenesis may continue up to 40 days postnatal in preterm neonates; however, they do not Hindawi International Journal of Nephrology Volume 2022, Article ID 4684674, 7 pages https://doi.org/10.1155/2022/4684674